Aptamers Market – Global Industry Analysis And Forecast (2023 to 2029)

Aptamers market was valued at US$ 150.99 Mn. in 2022 and is estimated to reach a value of US$ 472.50 Mn. in 2029. Global Aptamers Market size is estimated to grow at a CAGR of 17.7% over the forecast period.
Aptamers Market Overview:
Aptamers are single-stranded oligonucleotides that fold into defined architectures and bind to targets such as proteins. In binding proteins, they often inhibit protein-protein interactions and thereby may elicit therapeutic effects such as antagonism. Aptamers are discovered using SELEX (systematic evolution of ligands by exponential enrichment), a directed in vitro evolution technique in which large libraries of degenerate oligonucleotides are iteratively and alternately partitioned for target binding.

They are then amplified enzymatically until functional sequences are identified by the sequencing of cloned individuals. For most therapeutic purposes, aptamers are truncated to reduce synthesis costs, modified at the sugars and capped at their termini to increase nuclease resistance, and conjugated to polyethylene glycol or another entity to reduce renal filtration rates. Aptamers do not elicit antibodies, and because aptamers generally contain sugars modified at their 2′-positions, Toll-like receptor-mediated innate immune responses are also abrogated. As aptamers are oligonucleotides they can be readily assembled into supermolecular multi-component structures using hybridization.
Aptamers Market Snapshot
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The report explores the Aptamers Market segments (Type, Application, End-User, and Region). Data has been provided by market participants, and regions (North America, Asia Pacific, Europe, Middle East & Africa, and South America). This market report provides a thorough analysis of the rapid advances that are currently taking place across all industry sectors. Facts and figures, illustrations, and presentations are used to provide key data analysis for the historical period from 2017 to 2020. The report investigates the Aptamers Market's drivers, limitations, prospects, and barriers. This MMR report includes investor recommendations based on a thorough examination of the Aptamers Market's contemporary competitive scenario.
Aptamers Market Dynamics:
Increase in the number of Clinical Trials for Development of Aptamer-based Therapeutics Provides Growth to Market- The growing prevalence of life-threatening diseases, such as cancer, neurodegenerative, cardiovascular, and acquired immunodeficiency syndrome (AIDS), represents one of the key factors influencing the demand for new and effective detection assays based on aptamer therapy. The advent of the increase in the clinical trials for developing various other chemical modification processes to increase the nuclease resistance and enhance the therapeutic properties of aptamers is bolstering the market growth. The aptamers market growth can also be accredited to the rising number of research and development (R&D) activities undertaken for improving diagnostic devices and drugs and their carriers. Apart from this, as aptamers are chemically synthesized, which eliminates batch-to-batch variation and requires less time for development, their application is extensively increasing across the globe. Furthermore, private organizations are collaborating with academic institutes and research laboratories to introduce next-generation products and expand their existing market presence. This is anticipated to fuel the usage of aptamers in a wide range of medical therapies, as well as in the food and beverage (F&B) industry.

Increase in Awareness about Advantages of Aptamers as compared to Antibodies Improving Market Growth- The increase in the consumption by various industries of pharmaceuticals has encourages the market and the innovation drives the opportunity to provide market growth the major factor which provides awareness among the industries of their benefits is the properties it contains like aptamers are single-stranded DNA and RNA molecules that can selectively bind to a specific target. Aptamers can be found in a variety of shapes due to their tendency to form helices and also single-stranded loops. These are quickly generated and applied in the inhibition and characterization of proteins and further can be engineered to have higher specificity and affinity. These molecules are versatile and are used to bind targets including proteins, peptides, small molecules, toxins, carbohydrates, and even live cells. Aptamers are usually created by a selection process from a large random sequence pool and they, in turn, can be used for both clinical and research purposes.

Rising Prevalence of Chronic and Rare Diseases to Increase the Demand for Aptamer-Based Therapeutics and Diagnostics Propels the Growth- The increase in the various new and rare diseases which require new properties to fight the molecules and the aptamers are propelling to the numerous advantages offered by these small molecules, in comparison to established antibodies, have also led to higher demand for these molecules across a diverse range of medical applications. They are chemically synthesized, which eliminates batch-to-batch variation and demands less time for development. Along with this, continuous advancement in technologies is expected to stimulate market growth. According to a research study by US Healthcare Agency published in Electrochimica Acta Journal in April 2022, the study results found that aptamers have come into the spotlight as bio-mimetic molecular recognition elements in the field of biomedicine due to various applications in diagnostics, drug delivery, therapeutics, and pharmaceutical analysis. Aptamers are composed of nucleic acid strands (DNA or RNA) that can specifically interact in a three-dimensional tailored design with the target molecule.

Aptamers Market Trends:

The trend in the Venture Capital Funding for Research on Aptamers and growing collaborations Increased the Market Growth- Rising focus on the research and development activities in biotechnology and pharmaceutical sector to introduce innovative with various pharmaceutical drugs has propelled the growth of aptamers market. As per the reports by various Biotechnology Institutes, analyses that the aptamers market will exhibit a CAGR of around 20.16% for the forecast period of 2022-2029.

Rising Investment in Pharmaceutical R&D is the Opportunity Factor for Market-The huge investment by various governments and other institutes provides many key players opportunities to provide aptamers in low cost and high efficiency of aptamers in binding to large molecules as compared to antibodies coupled with an increased focus to improve the technology are the major factors fuelling the aptamers market value. Increased research and development proficiencies in the biotechnology and pharmaceutical industry have also induced the growth of the aptamers market. The rising focus on aptamers for drug discoveries and disease treatment coupled with the increased production of recombinant products have led to the creation of lucrative aptamers market growth opportunities. Growing FDA approvals too have fostered the growth of the market and have given a push to the market growth rate.

Aptamers Market Restraints-

Low Market Acceptance as Compared to Antibodies is likely to Restrain the Market Growth- Ethical issues regarding aptamers as they are obtained from animals will restrict the scope of application for the market. Stringent regulations imposed on the use and application of aptamers will also pose a restraining factor to the growth of the market. The dearth of trained experts will further dampen the market growth rate. A low technological base in low and middle-class economies coupled with an unstructured regulatory system will further hammer down the market growth. One of the major drawbacks of aptamers is their low affinity. Even if aptamers can target a wide variety of molecules, studies have shown that they do not have high affinities for all types of molecules. The oligonucleotide structure of aptamers can limit certain interactions between the aptamer and the target molecule. Additionally, aptamers targets are mostly present in blood plasma or cells that are accessible from blood plasma. This leads to their exposure to renal filtration, nuclease degradation, or liver or spleen uptake. Hence, despite their advantages over antibodies, aptamers have low market acceptance and low adoption potential within the scientific society, which results in low market penetration. This is likely to restrain the growth of the market.
Aptamers Market Segment Analysis:
Based on Type, the Aptamers Market is segmented into DNA Aptamers, XNA Aptamers, and RNA Aptamers.
Aptamers Market, by Type in 2022(%)


DNA-Aptamers are the most dominating market which holds a market size of more than 30% and provides a growth rate of 7.5% in a year the factors attributing to the market growth is the aptamers are single-stranded DNA molecules that can selectively bind to a specific target. Aptamers can be found in a variety of shapes due to their tendency to form helices and also single-stranded loops. These are quickly generated and applied in the inhibition and characterization of proteins and further can be engineered to have higher specificity and affinity. These molecules are versatile and are used to bind targets including proteins, peptides, small molecules, toxins, carbohydrates, and even live cells. Aptamers are usually created by a selection process from a large random sequence pool and they, in turn, can be used for both clinical and research purposes and propels the segment growth.

Based on Application, the Aptamers Market is segmented into Therapeutics Development, Research & Development, Diagnostics, and Others.
Aptamers Market, by Application in 2022 (%)


Diagnostics holds the largest market share and the factors owing to the market growth because of the increasing number of clinical trials evaluating aptamers for new therapies and collaborations among aptamer companies & prominent pharmaceutical and biotechnology firms. The diagnostic segment is projected to grow at the highest CAGR due to the increasing prevalence of chronic diseases and the development of new diagnostic kits to detect cancer and other diseases.

Based on End-User, the Aptamers Market is segmented into Pharmaceuticals & Biotechnology Companies, Academic & Government Research Institutes, CROs, and Others.
Aptamers Market, by End User in 2022(%)


pharmaceutical & biotechnology companies in the major segment which hold the largest market segment in the aptamers market, the factors improving the segment is the increase of the consumption of aptamers in 2020 dominated the market and the other factors owing to the increasing number of market players offering custom aptamers for use in therapeutics development & rising R&D expenditure. The segment will record the highest CAGR during the forecast period due to the development of diagnostic tools for cancer and infectious diseases.
Aptamers Market Regional Insights:
Asia-Pacific Aptamers Market region is expected to witness significant growth at a CAGR of 12.5% through the forecast period. The Asian Pacific region dominates the aptamers market due to rapid technological advancements and high investment and funding to support the development of aptamers. China has been the hub of all major R and D activities related to aptamers. The first aptamer therapeutic product ''Macugen'' was approved in 2020 by the US FDA (United States Food and Drugs Administration).

Aptamers, explicitly synthesized for the nucleocapsid protein of SARS-CoV-2, are deployed and provide a rapid result. No refrigeration or preparation of the sample is required. The nano sensor-based essay will be able to detect COVID-19 in both symptomatic and asymptomatic cases accurately and distinguish the novel coronavirus from influenza and other common respiratory pathogens. According to a Canadian research study by Jiuxing Li et al., published in Nucleic Acids Research Journal, June 2022, the study results found that aptamers maintained full binding activity with the S1 protein spiked into 50% human saliva, which could support home-testing or rapid testing in congregate settings. Based on this finding, developed a simple colorimetric sandwich assay using the MSA1 aptamer as molecular recognition elements (MRE) and showed that it was capable of detecting pseudotyped lentivirus in 40% saliva with a limit of detection of 300 fM. The study has confirmed the potential of the aptamers as diagnostic tools for pandemic detection in an easily accessed patient sample.

The objective of the report is to present a comprehensive analysis of the Aptamers Market to the stakeholders in the industry. The past and current status of the industry with the forecasted market size and trends are presented in the report with the analysis of complicated data in simple language. The report covers all the aspects of the industry with a dedicated study of key players that include market leaders, followers, and new entrants.

PORTER, PESTEL analysis with the potential impact of micro-economic factors of the market have been presented in the report. External as well as internal factors that are supposed to affect the business positively or negatively have been analyzed, which will give a clear futuristic view of the industry to the decision-makers.

The reports also help in understanding the Aptamers Market dynamic and structure by analyzing the market segments and projecting the Aptamers Market size. Clear representation of competitive analysis of key players by Design, price, financial position, product portfolio, growth strategies, and regional presence in the Aptamers Market make the report investor’s guide.
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Global Aptamers Market


Report Coverage
Details


Base Year:
2022
Forecast Period:
2023-2029


Historical Data:
2018 to 2022
Market Size in 2022:
US$ 150.99 Mn.


Forecast Period 2023 to 2029 CAGR:
17.7%
Market Size in 2029:
US$ 472.50 Mn.


 Segments Covered:
by Type
DNA Aptamers
XNA Aptamers
RNA Aptamers


by Application
Therapeutics Development
Research & Development
Diagnostic
Others


by End-User
Pharmaceuticals & Biotechnology Companies
Academic & Government Research Institutes
CROs
Others



Aptamers Market, by Region
North America (United States, Canada and Mexico)
Europe (UK, France, Germany, Italy, Spain, Sweden, Austria, Turkey, Russia and Rest of Europe)
Asia Pacific (China, India, Japan, South Korea, Australia, ASEAN and Rest of APAC)
Middle East and Africa (South Africa, GCC, Egypt, Nigeria and Rest of ME&A)
South America (Brazil, Argentina, Columbia and Rest of South America)
Aptamers Market, Key Players are
1. Somal Logic
2. Aptamer Group
3. Aptamer Science
4. Base Pair Biotechnologies
5. NOXXON Pharma
6. Vivonics Inc.
7. Aptagen, LLC
8. TRI LINK Biotechnologies
9. Aptagen Biotech, S.L
10. IBA GmbH
11. Kaneka Eurogentec
12. NEO VENTURES Biotechnology, Inc.

Frequently Asked Questions:

1] What segments are covered in the Aptamers Market report?
Ans. The segments covered in the Aptamers Market report are based on Material, Equipment, and Prosthetic Type.

2] Which region is expected to hold the highest share in the Aptamers Market?
Ans. The Asia-Pacific region is expected to hold the highest share in the Aptamers Market.

3] What is the market size of the Aptamers Market by 2029?
Ans. The market size of the Aptamers Market by 2029 is expected to reach USD 472.50 Million.

4] What is the forecast period for the Aptamers Market?
Ans. The forecast period for the Aptamers Market is 2022-2029.

5] What was the market size of the Aptamers Market in 2022?
Ans. The market size of the Aptamers Market in 2022 was valued at USD 150.99 Million.