Protein Sequencing Market: Global Industry Analysis and Forecast (2023-2029)

Protein Sequencing market which is at USD 1.34 Billion, is estimated to grow at a CAGR of 3.77% in the forecasted period. The forecasted revenue hints at a growth of around 1.73 billion USD by 2029.

Protein Sequencing is the process of determining the amino acid sequence or understanding conformations of an entire peptide or small fragment of a protein sequence aiding in the analysis of the cellular structure. The market is showing a growing trend especially during current times, where focus on biotechnology has gathered huge interest. Recent research has ushered new dimensions of Protein sequencing market like, a natural allele of proteosome maturation factor improving rice resistance against pathogen.

Similarly, with increasing applications, the market is growing with it simultaneously. Entry barriers are often very high in such a niche market like protein sequencing and is dominated by the giants having huge financial backing. The big firms have mainly subjugated the market leaving little for smaller firms. Yet, with increasing demand and a dynamic change in innovation and research, the market has showed signs of huge success which is evident from the annual growth.
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Protein Sequencing market Market Dynamics
Driving huge opportunities in the Protein Sequencing market

High investments in R&D and huge development in the technology have opened opportunities for Protein sequencing, along with significant players entering the sequencing market like 10X genomics. Also rising focus on target-based drugs have enabled developments in this field. Advancement in mass spectroscopy and other equipment’s have assured that protein sequencing develops. Increased number of institutions offering labs for researchers to work at a lower cost have increased which also helped in creating a boost for this market. Example - NVIDIA corporation announced combination of cloud service with BioNeMo, which would offer researchers biology models and pre trained programs for

understanding. Mass spectroscopy, one of its segments is projected at 2.9% CAGR and reach 750 million USD. If we focus only on US, which is one of the largest markets is contributing 281.5 million, while China is showing an annual growth of 3%. De novo protein sequencing has helped overcome limitations of peptide mass fingerprinting (PMF) which increased database dependency. Also, innovations regarding the identification of single amino acids in bulk along with Edman degradation, has opened new corridors for the protein sequencing market. As Protein sequencing has a lot of applications in various domains like Biotherapeutics, Genetic engineering, also peptide mapping is an important step in the process of Genetic reengineering.

Gene modification or to attach an identified probe, this analysis of proteins is equally important. An increase in demand for proteins to be used for biomarkers have opened an opportunity for the new emerging players. Along with proteomics and drug development, recent opportunities are available in agriculture sector to study crops and their modifications which can harvest more while keeping the quality. Biomarker discovery and Clinical diagnostics can show applications of Protein sequencing. Protein engineering is one of the segments which is upcoming and has shown huge potential in protein sequencing market. The market has a growth potential of around 1340 million USD

Challenges which need to be tackled

High cost to setup infrastructure is seen as a huge challenge along with unavailability of resource. The purity of the sample is always questioned as impure sample can give false positive results. The unavailability of expertly skilled scientists and researchers has been a constraint in the industry. Post-translational modifications can alter the functions and activity. PTMs can make protein sequencing more challenging, as they can affect the behaviour of the protein during the sequencing process. Inability to distinguish between novel PPIs and false positive results. Some significant challenges in front of the industry are regarding high cost of equipment and sophisticated software.

Also, the lack of skilled professionals to handle such equipment is posing a huge challenge for the market. Improper data analysis and segregated protocols across labs have come across as an emerging issue in front of the market leaders. Protein sequencing requires a lot of accuracy to figure out bases which requires accurate equipment’s and skilled hands. With mass spectroscopy comes the challenge of calibration and sample preparation which also can make this process a bit difficult.

Also, the sensitivity can be limited by the complexity of the sample, the size of the molecules, or the ionization efficiency of the molecule. Overfitting and underfitting issues can occur when generating predictive models. The performance of a predictive model generated by a learning algorithm depends on how well it captures the underlying features of the training dataset. Sanger sequencing can only detect 15-20% of mosaic variants which is again a huge challenge in terms of purity of the protein

Market Trends Protein Sequencing

The rising demand for protein degradation is evident as Amphista Therapeutics and Bristol Meyers Squibb collaborated to develop small molecule protein degrades which assisted in increasing the application of Protein sequencing. As per WHO, it has approximately awarded 80178 grants to biomedical research field in 2019 which has shown its increase in investments post pandemic. Also, significant public-private financial support for research has helped researchers invest heavily on R&D. Techniques like Nanopore sequencing has the capabilities to revolutionize sequencing as it allows direct sequencing of individual protein molecules. Along with increasing interest in PTMs and phosphorylation, such modifications and their applications are emerging as new trends.
Protein Sequencing market Segmentation
Based on Technology

The protein sequencing market is classified based on its technologies - Edman degradation and Mass spectrometry-based sequencing. Edman degradation is mostly predominant in current scenario as it can be widely used. It also takes less time for protein sequencing and does not damage the protein in the process.

While, mass spectrometry is the segment which is showing a very high growth rate and has a larger market share in protein sequencing market. As long chain protein sequencing is possible through Mass spectroscopy it gives an added advantage. Also, the technique is rapid, and highly accurate and does not require a prerequisite of pure protein at the start of the process.

Based on Application

The protein sequencing market is classified based on its applications – Biotherapeutics, Protein engineering, Proteomics research and clinical diagnostics. As investments have increased in research, proteomics research has started blooming along with its other applications.

While, protein engineering is showing the fastest growth because of its added advantage that it can change the metabolic drug landscape and also form unnatural polypeptides easily.

Biotherapeutics is a large segment which caters to prevention of diseases, ADME and translational pharmacokinetics of Therapeutic Proteins has ushered as enhanced field with high scope.

Based on End User

The protein sequencing market can be classified based on its End user - pharmaceutical and biotechnology companies, academic research institutes, and clinical laboratories. The pharmaceutical companies have an established market and thus show a good market share because of its high requirements.

Clinical laboratories are also increasing because of high investments in the field.
While academic institutes are enjoying a larger market share which constitutes nearly 50%

Based on Region

The protein sequencing market can be classified based on its regions – North America, Asia – Pacific, Middle East and Africa, Europe and South America. North America is the dominant player in the protein sequencing industry where it nearly caters to 35% of the entire market. Asia Pacific, is the growing market because of high investments in research and development especially after the pandemic. Europe is also predominant because of its core players like Germany and Switzerland who are holding high market share in the protein sequencing market. While South America and Middle eastern countries are also slowly increasing its market share due to increasing investments.

Regional Insights

Global

Globally the market is spread across all the continents, where North America and Europe have been the leaders in terms of revenue because of high investments. The United States, in particular, has a significant share in the protein sequencing market due to the presence of a large number of biotechnology and pharmaceutical companies, academic research institutes, and government initiatives promoting protein sequencing research. Also, the presence of advanced healthcare infrastructure and the availability of funding for research and development has contributed to the growth of the protein sequencing market in the United States.

North America

The US is one of the leading countries in terms of revenue and market share of the protein sequencing industry. The US has well-established facilities with adequate advancement in technologies to work on protein sequencing. While Canada is falling behind the US, it has taken significant measures to replicate the success of its neighbour. Canada is also home to a growing number of research institutions and biotechnology companies that are actively involved in protein sequencing research which they are leveraging to increase their market share. With Mexico, it has a large pharmaceutical industry which provides opportunities for protein sequencing companies to partner with local pharmaceutical companies and gain some significant control over the market

Asia Pacific

The market in Asia Pacific is significantly showing rapid growth which is a result of a huge population and two strong countries - India and China. Increased investments in biotechnology, rising healthcare spending, and the occurrence of the virus, all have contributed to a rapid surge of the industry in the Asia Pacific region. Both India and China have well-developed resources and techniques to enlarge their market share. Irrespective of these two, even Japan and South Korea have emerged as upcoming markets due to their high investment in life sciences and overall R&D

Europe

Europe is another dominant player in the market, where Germany and UK lead the way in the protein sequencing market. The intact healthcare market and growing investments have helped Europe dominate this industry. The European Union's Horizon 2020 program has provided funding for research and development projects in the life sciences sector, including protein sequencing research. The UK is home to several prominent protein sequencing companies and research institutions which has helped itself gain a huge market share along with Germany and France. All the 3 countries have relied on huge investments, and proper facilities which have made them one of the most prominent leaders in the market

Middle East and Africa

The protein sequencing market is still in the early stages for both regions. Recently the Middle East has increased its focus on biotechnology and research which will give the country a boost in this sector. United Arab Emirates (UAE) and Saudi Arabia are the largest markets for protein sequencing in the region, due to their growing economies, significant investment in healthcare infrastructure, and increasing focus on research and development. Other countries in this region, such as Egypt, South Africa, and Morocco, are also expected to contribute to the growth of the protein sequencing market in the coming years.

South America

The protein sequencing market in South America is growing steadily, and Brazil and Argentina are emerging as the dominant players. Both countries have spent huge amounts of dollars to sustain this protein sequencing market. Huge demand and established facilities have helped Brazil and Argentina gain a good share of the market in this industry. Along with these two, even Chile, and Peru are emerging markets that have the potential to compete with the two main players of the South American continent

Competitive Landscape

The protein sequencing industry is highly competitive, with several established players and a large number of emerging companies aiming to gain the maximum market share. The industry is growing significantly as its facing huge demand because of the increase in research and development projects across the globe. Thermo Fischer is the market leader and provider of analytical instruments, reagents, software, services, and consumables for the life sciences industry. The company offers a range of protein sequencing solutions, including mass spectrometry-based protein identification and characterization, peptide mapping, and de novo sequencing. It is positioned as reliable and has a huge market demand and consumer loyalty. The company has a strong product portfolio and holds control over the regions of North America, Asia Pacific, and Europe.

Agilent Technologies is another strong player from the US which offers a wide range of protein sequencing solutions and has a good geographical hold over its market. The company's protein sequencing solutions include mass spectrometry-based protein identification and characterization, peptide mapping, and intact protein analysis. Shimadzu Corporation is another Japanese multinational corporation that manufactures and sells a range of analytical and measuring instruments, including mass spectrometers.

The company's protein sequencing solutions include mass spectrometry-based protein identification and characterization. In recent years, Shimadzu has made several strategic acquisitions and partnerships to strengthen its position in the life sciences market. For example, in 2018, Shimadzu acquired AlsaChim, a French manufacturer of analytical standards for mass spectrometry-based applications. Thus, Shimadzu is trying to expand over Europe and America to gain a higher market share.
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Protein Sequencing Protein Market


Report Coverage
Details


Base Year:
2022
Forecast Period:
2023-2029


Historical Data:
2017 to 2022
Market Size in 2022:
USD 1.34 Bn.


Forecast Period 2023 to 2029 CAGR:
3.77 %
Market Size in 2029:
USD 1.77 Bn.


 Segments Covered:
by Application
1. Biotherapeutics
2. Protein Engineering
3. Proteomics research


by Region
1. North America
2. Asia Pacific
3. Europe
4. Middle East and Africa
5. South America


by Technology
1. Edman Degradation
2. Mass Spectroscopy


by End - User
1. Pharma companies
2. Research institutions
3.  Research Laboratories



Protein Sequencing Protein Market, by Region
North America (United States, Canada and Mexico)
Europe (UK, France, Germany, Italy, Spain, Sweden, Austria, Turkey, Russia and Rest of Europe)
Asia Pacific (China, India, Japan, South Korea, Australia, ASEAN and Rest of APAC)
Middle East and Africa (South Africa, GCC, Egypt, Nigeria and Rest of ME&A)
South America (Brazil, Argentina, Columbia and Rest of South America)
Protein Sequencing Protein Market, Key Players are
1. Thermo Fischer Scientific (US)
2. Waters Corporation (US)
3. Agilent Technologies Inc. (US)
4. Bruker Corporation (US)
5. Bio-Rad Laboratories, Inc. (US)
6. Promega Corporation (US)
7. GE Healthcare (US)
8. Danaher Corporation (US)
9. PerkinElmer, Inc. (US)
10. Charles River Laboratories (US)
11. Levita Magnetics (US)
12. Praxis Biotech (US)
13. Rapid Novor Inc (Canada)
14. Bioinformatics Solutions (Canada)
15. Selvita SA (Poland)
16. Proteome Factory (Germany)
17. Biofidus AG (German)
18. Qiagen N.V. (Germany)
19. Genedata AG (Switzerland)
20. SGS SA (Switzerland)
21. Genedata AG (Switzerland)
22. Quantum Si (UK)
23. Shimadzu corporation (Japan)
24. Takara Bio Inc (Japan)
25. GeneX India (India)
26. GeneproDX (Chile)

FAQs

1 Which region has the most growing potential across globe?
Ans: Asia Pacific region is showing the highest amount of growth rate.

2 What is the growth rate of Protein sequencing market?
Ans: The CAGR for the market is around 3.77%.

3 What are the key market segments of this industry
Ans: The key segments are mainly classified on technology – Mass spectroscopy and Edman degradation and based on end users – Pharmaceutical companies, clinical laboratories and academic researches.

4 What is the study period of the market?
Ans: The study is forecasted from the year 2023 – 2029.

5 Which companies are prominent in the market share?
Ans: Thermo Fisher Scientific, SGS SA, Shimadzu are some prominent players in the market.