3D Cell Culture Market – Global Industry Analysis And Forecast(2021-2029)

3D Cell Culture Market was valued at USD 1.66 Billion in 2021, and it is expected to reach USD 3.77 Billion by 2029, exhibiting a CAGR of 10.8 % during the forecast period (2022-2029) The Global 3D Cell Culture Market is segmented by technology, application, and end-users. Based on technology, the market is segmented into scaffold-based (hydrogels, polymeric scaffolds, micro-patterned surface microplates, nanofiber-based scaffolds), scaffold-free (hanging drop microplates, microfluidic 3d cell culture, spheroid microplates with ULA coating, magnetic levitation & 3D bioprinting), and bioreactors. Based on application, the market is segmented into cancer, tissue engineering & immunohistochemistry, drug development, stem cell research, and others. Based on end-users, the market is segmented into biotechnology and pharmaceutical industries, research laboratories and institutes, hospitals and diagnostic centers, and others. Based on region, the market is segmented into North America, Asia Pacific, Europe, Middle East & Africa, and South America. 3D Cell Culture Market To know about the Research Methodology :- Request Free Sample Report In research that call for in vivo model systems to examine the effects of a foreign substance upon bodily tissues and organs, 3D cultures are frequently utilised since they can accurately replicate the usual morphology and microarchitecture of organs. Moreover, a significant number of research entities adopted 3-dimensional cell culture techniques due to the biomimetic tissue constructions employed to produce 3D organotypic structures. Additionally, a new approach to conventional methods for treating Covid-19, cancer, and other clinical illnesses has emerged: using 3D tissue-engineered models. In comparison to 2D approaches, this also has significant promise in terms of offering a very straightforward and affordable in vitro tumor-host environment. COVID-19 Impact on 3D Cell Culture Market After the WHO formally declared the COVID-19 outbreak to be a pandemic, a number of well-known pharmaceutical and biopharmaceutical firms increased their R&D and production efforts to create and distribute test kits, vaccines, and medications against the SARS-CoV-2 virus. Viral vaccines based on cell culture are used to immunise people against illnesses all over the world. The SARS-CoV-2 virus is now cultured in mammalian cell lines for research purposes. When producing medicines with the correct amount of pharmacological efficacy, culture media provide the nutrients and component cells needed for growth under carefully regulated environmental circumstances. Products for 3D cell culture, including scaffolds, bioreactors, vessels, and apparatus, aid scientists in studying cellular behaviour to replicate in vivo circumstances. Developing substrates for the secure manufacture of viral vaccines is a continual process known as cell culture. To combat and stop the spread of the coronavirus, however, escalating worldwide demand and tight safety regulations have compelled scientists and vaccine producers to create cell culture-based vaccinations. Due to expanded research efforts, this development had enhanced the need for 3D cell culture goods in 2020 and 2021. One of the top producers of bioprocesses claims that the market for bioprocessing solutions has been able to handle the pandemic's effects on supply chains, manufacturing, and shipments to consumers. On the market for 3D cell culture, however, the effect has been minimal.

3D Cell Culture Market Dynamics

Increasing focus on developing alternatives to animal testing: In cell biology research, animal models are frequently employed to examine illnesses that only affect humans. However, this approach has a number of drawbacks, including the potential for animal suffering and challenges assuring result accuracy because of a variety of factors, including species variations, disease causes, and treatment responses. Alternative approaches to drug development are being developed by a number of institutes to address these problems. Several European legislation significantly support the replacement of animal testing, including the Classification, Labeling, and Packaging (CLP) (1272/2008), REACH (2007/2006), Cosmetic Products Regulation (1223/2009), and Directive on the Protection of Animals Used for Scientific Purposes (2010/63). The use of animal-based models for research is also opposed by the Canadian Centre for Alternatives to Animal Methods, the Canadian Centre for the Validation of Alternative Methods, Cruelty Free International, and the Fund for the Replacement of Animals in Medical Experiments. Emergence of microfluidics-based 3D cell culture: Microenvironments that facilitate tissue development, duplicate the tissue-tissue interface, spatiotemporal chemical gradients, and mechanical microenvironments of biological organs, may now be created using microfluidics in 3D cell culture thanks to recent advancements. The study of human physiology in an organ-specific environment is made possible by this organ-on-a-chip model, which also paves the way for the creation of in vitro disease models and, ultimately, a substitute for animal models in drug development and toxicity assessment. To improve their market position, major competitors in the market are forming alliances and working together with pharmaceutical firms. With the use of this tactic, market participants may assess how well their organs-on-chips products work during the medication development and subsequent stages of pharmaceutical research. For instance, in November 2021, CN Bio began a research partnership aimed at testing cutting-edge infection models for organs on chips. In order to evaluate new drugs in inflammatory bowel disease (IBD) and hepatitis B virus infections, MIMETAS and Roche teamed together in July 2021. (HBV). Lack of consistency in 3D cell culture products: The variety of research options has increased with the usage of scaffold-based 3D cell cultures. However, the inclusion of several growth factors in scaffolds results in their batch-to-batch variability, which obstructs pharmacological research and biological studies of signalling networks. To address this issue, growth-factor-reduced scaffolds have been created, such as Matrigel Matrix (Corning). Although the morphologies of the cells grown on scaffolds with low growth factors were comparable to those of the cells placed on scaffolds with high growth factors, the proliferation rate was very high. Additionally, cells developed on scaffolds with minimal growth factors cannot be authorised for human implantation. This demonstrates the requirement for materials that give ECM's inherent functionality as well as the capacity to customise biological and material features. Synthetic scaffolds, like synthetic peptides, should soon be able to overcome this barrier; nevertheless, until they are available, the industry will continue to face significant consistency issues.

3D Cell Culture Market Segment Analysis

Based on technology, the market is segmented into scaffold-based (hydrogels, polymeric scaffolds, micro-patterned surface microplates, nanofiber-based scaffolds), scaffold-free (hanging drop microplates, microfluidic 3d cell culture, spheroid microplates with ULA coating, magnetic levitation & 3D bioprinting), and bioreactors. In 2021, scaffold-based technology had the highest revenue share (more than 69.7%). In 3-dimensional cell culture-based research, the use of hydrogels as scaffolds enables the inclusion of complex biochemical and mechanical indications as a mirror of the natural extracellular matrix. Additionally, the introduction of innovative products and the growing need for hydrogel developments to provide stable platforms for researching human and cellular physiology are anticipated to fuel market growth during the forecast period. In January 2021, scientists from China's Southern University of Science and Technology created a technique for 3D printing hydrogels that are incredibly stretchy. This aids in overcoming the drawbacks of hydrogel-polymer-based scaffolds' functionality and performance. Adocia, a biopharmaceutical business with headquarters in Paris, created a hydrogel scaffold in January 2021 that can be utilised for cell treatment for Type 1 diabetes. The increased acceptance of nanotechnology in biomedical research is expected to open up new opportunities for growth for nanofiber-based scaffolds, boosting both demand and sales for the scaffold-based technology. The label- and scaffold-free technique of magnetic levitational assembly of 3D tissue constructs is a new and rapidly developing method for tissue engineering. Over the forecast period, this is estimated to drive the scaffold-free segment with the quickest CAGR. 3D Cell Culture Market Based on application, the market is segmented into cancer, tissue engineering & immunohistochemistry, drug development, stem cell research, and others. In 2021, the cancer market sector held a commanding 25.7 % revenue share. R&D in this segment is driven by the development of anticancer medicines using spheroids as model systems. Additionally, it is expected that the adoption of three-dimensional cell models for the analysis of cancer biology in preclinical testing and screening would boost revenue creation in this market. Polysaccharide hydrogel-based 3D printed tumour models have been developed, and they may be utilised for high throughput testing of anti-cancer medications, according to a research article published in January 2021. In this work, the researchers sought to create a hydrogel that accurately mimics the tumour microenvironment and exhibits the necessary biocompatibility, rheological properties, and printability. Such advancements encourage the employment of scaffold-based cancer treatment methods more often. During the forecast period, the industry segment for stem cell research is estimated to register the quickest CAGR. The segment is expected to develop as more 3D cell culture platforms are used for regenerative medicine. Histogen, Inc., a business involved in the research and development of regenerative medicine, and Conatus Pharmaceuticals, Inc., agreed into a merger agreement in January 2020. The latter presents a strong pipeline of novel therapeutic options, including an extracellular matrix scaffold intended for the treatment of articular cartilage-related diseases. 3D Cell Culture Market Based on end-users, the market is segmented into biotechnology and pharmaceutical industries, research laboratories and institutes, hospitals and diagnostic centers, and others. The biotechnology and pharmaceutical segment provided the biggest revenue share of more than 46% in 2020. In compared to 2D cell cultures, 3D cell cultures provide benefits in terms of appropriate oxygen and nutritional gradients, non-uniform exposure of cells within a spheroid to a drug, and realistic cell-to-cell interactions. These elements make 3D cell cultures more suitable for the discovery and development of new drugs, which is further driving the market. The expansion of the hospitals and diagnostic centres market is aided by factors like the pressing demand for quicker and more accurate diagnostic services and the superiority of 3D models over 2D models in terms of giving comprehensive physiological data. Additionally, the presence of diagnostic facilities like Kiyatec, which actively provide 3D models for cutting-edge research, is expected to accelerate the segment's growth in the upcoming years. Industrial laboratories and academic institutions are estimated to contribute in the growth of the market. Over the forecast period, demand for 3D cell culture goods & systems is expected to be driven by workshops and training programmes on 3D cell culture systems offered by institutes. 3D Cell Culture Market

3D Cell Culture Market Regional Insights

In 2021, North America held a dominating 45 % market share of the 3D Cell Culture market. Due to the availability of private and public funding for the development of advanced 3D cell culture models, high healthcare spending, and the presence of numerous universities and research organisations looking into various stem cell-based approaches, the region will continue to dominate during the forecast period. Researchers from the Terasaki Institute and Mayo Clinic in the United States created transparent hydrogels that may be utilised for haemorrhage monitoring and management in December 2020. Regenerative medicine is acknowledged as being at the vanguard of healthcare by the "2020: A New Vision" project of the U.S. Department of Health and Human Services. For translational research and technological innovation, the transformational effect of regenerative medicine application at the clinical stage is crucial. Asia Pacific region is estimated to witness the quickest rate of regional market growth from 2022 to 2029 due to increased investments by several multinational firms in this region's rising economies. In Asia Pacific region, countries like India, China, Taiwan, Malaysia, and Japan are estimated to witness a boost in demand for 3D cell culture products and are expected to register maximum growth over the next five-six years, as a result of their economic development, rising awareness regarding cancer in these countries, huge production of drugs in this region, and the growing focus of 3D cell culture players in these markets.

3D Cell Culture Market Scope: Inquire before buying

Global 3D Cell Culture Market
Report Coverage Details
Base Year: 2021 Forecast Period: 2022-2029
Historical Data: 2017 to 2021 Market Size in 2021: US 1.66 Bn.
Forecast Period 2022 to 2029 CAGR: 10.8 % Market Size in 2029: US 3.77 Bn.
Segments Covered: by Technology • Scaffold-based o Hydrogels o Polymeric Scaffolds o Micro-patterned Surface Microplates o Nanofiber-based Scaffolds • Scaffold-free o Hanging Drop Microplates o Microfluidic 3D Cell Culture o Spheroid Microplates with ULA coating o Magnetic Levitation & 3D Bioprinting • Bioreactors
by Application • Cancer • Tissue Engineering & Immunohistochemistry • Drug Development • Stem Cell Research • Others
by End-Users • Biotechnology and Pharmaceutical Industries • Research Laboratories and Institutes • Hospitals and Diagnostic Centers • Others

3D Cell Culture Market by Region:

• North America • Europe • Asia Pacific • The Middle East and Africa • South America

3D Cell Culture Market Key Players:

Merck KGaA • Thermo Fisher Scientific, Inc. • Greiner Bio One International GmbH • Corning, Inc. • 3D Biomatrix • Lonza • PromoCell GmbH • Avantor Performance Materials, LLC • Tecan Trading AG • 3D Biotek LLC • Global Cell Solutions, Inc. • InSphero Frequently Asked Questions: 1] What segments are covered in the Global 3D Cell Culture Market report? Ans. The segments covered in the 3D Cell Culture Market report are based on Technology, Application, End-Users. 2] Which region is expected to hold the highest share in the Global 3D Cell Culture Market? Ans. The North America region is expected to hold the highest share in the 3D Cell Culture Market. 3] What is the market size of the Global 3D Cell Culture Market by 2029? Ans. The market size of the 3D Cell Culture Market by 2029 is expected to reach USD 3.77 Bn. 4] What is the forecast period for the Global 3D Cell Culture Market? Ans. The forecast period for the 3D Cell Culture Market is 2021-2029. 5] What was the market size of the Global 3D Cell Culture Market in 2021? Ans. The market size of the 3D Cell Culture Market in 2021 was valued at USD 1.66 Bn.
1. Global 3D Cell Culture Market Size: Research Methodology 2. Global 3D Cell Culture Market Size: Executive Summary 2.1. Market Overview and Definitions 2.1.1. Introduction to Global 3D Cell Culture Market Size 2.2. Summary 2.2.1. Key Findings 2.2.2. Recommendations for Investors 2.2.3. Recommendations for Market Leaders 2.2.4. Recommendations for New Market Entry 3. Global 3D Cell Culture Market Size: Competitive Analysis 3.1. MMR Competition Matrix 3.1.1. Market Structure by region 3.1.2. Competitive Benchmarking of Key Players 3.2. Consolidation in the Market 3.2.1 M&A by region 3.3. Key Developments by Companies 3.4. Market Drivers 3.5. Market Restraints 3.6. Market Opportunities 3.7. Market Challenges 3.8. Market Dynamics 3.9. PORTERS Five Forces Analysis 3.10. PESTLE 3.11. Regulatory Landscape by region • North America • Europe • Asia Pacific • The Middle East and Africa • South America 3.12. COVID-19 Impact 4. Global 3D Cell Culture Market Size Segmentation 4.1. Global 3D Cell Culture Market Size, by Technology (2021-2029) • Scaffold-based o Hydrogels o Polymeric Scaffolds o Micro-patterned Surface Microplates o Nanofiber-based Scaffolds • Scaffold-free o Hanging Drop Microplates o Microfluidic 3D Cell Culture o Spheroid Microplates with ULA coating o Magnetic Levitation & 3D Bioprinting • Bioreactors 4.2. Global 3D Cell Culture Market Size, by Application (2021-2029) • Cancer • Tissue Engineering & Immunohistochemistry • Drug Development • Stem Cell Research • Others 4.3. Global 3D Cell Culture Market Size, by End-Users (2021-2029) • Biotechnology and Pharmaceutical Industries • Research Laboratories and Institutes • Hospitals and Diagnostic Centers • Others 5. North America 3D Cell Culture Market (2021-2029) 5.1. North America 3D Cell Culture Market Size, by Technology (2021-2029) • Scaffold-based o Hydrogels o Polymeric Scaffolds o Micro-patterned Surface Microplates o Nanofiber-based Scaffolds • Scaffold-free o Hanging Drop Microplates o Microfluidic 3D Cell Culture o Spheroid Microplates with ULA coating o Magnetic Levitation & 3D Bioprinting • Bioreactors 5.2. North America 3D Cell Culture Market Size, by Application (2021-2029) • Cancer • Tissue Engineering & Immunohistochemistry • Drug Development • Stem Cell Research • Others 5.3. North America 3D Cell Culture Market Size, by End-Users (2021-2029) • Biotechnology and Pharmaceutical Industries • Research Laboratories and Institutes • Hospitals and Diagnostic Centers • Others 5.4. North America 3D Cell Culture Market, by County(2021-2029) • United States • Canada 6. European 3D Cell Culture Market (2021-2029) 6.1. European 3D Cell Culture Market , by Technology (2021-2029) 6.2. European 3D Cell Culture Market , by Application (2021-2029) 6.3. European 3D Cell Culture Market , by End-Users (2021-2029) 6.4. European 3D Cell Culture Market , by Country (2021-2029) • UK • France • Germany • Italy • Spain • Sweden • Austria • Rest Of Europe 7. Asia Pacific 3D Cell Culture Market (2021-2029) 7.1. Asia Pacific 3D Cell Culture Market , by Technology (2021-2029) 7.2. Asia Pacific 3D Cell Culture Market , by Application (2021-2029) 7.3. Asia Pacific 3D Cell Culture Market , by End-Users (2021-2029) 7.4. Asia Pacific 3D Cell Culture Market , by Country (2021-2029) • China • India • Japan • South Korea • Australia • ASEAN • Rest Of APAC 8. Middle East and Africa 3D Cell Culture Market (2020-2029) 8.1. Middle East and Africa 3D Cell Culture Market , by Technology (2021-2029) 8.2. Middle East and Africa 3D Cell Culture Market , by Application (2021-2029) 8.3. Middle East and Africa 3D Cell Culture Market , by End-Users (2021-2029) 8.4. Middle East and Africa 3D Cell Culture Market , by Country (2021-2029) • South Africa • GCC • Egypt • Nigeria • Rest Of ME&A 9. South America 3D Cell Culture Market (2020-2029) 9.1. South America 3D Cell Culture Market , by Technology (2021-2029) 9.2. South America 3D Cell Culture Market , by Application (2021-2029) 9.3. South America 3D Cell Culture Market , by End-Users (2021-2029) 9.4. South America 3D Cell Culture Market , by Country (2021-2029) • Brazil • Mexico • Argentina • Rest Of South America 10. Company Profile: Key players 10.1. Merck KGaA 10.1.1. Company Overview 10.1.2. Financial Overview 10.1.3. Global Presence 10.1.4. Capacity Portfolio 10.1.5. Business Strategy 10.1.6. Recent Developments 10.2. Thermo Fisher Scientific, Inc. 10.3. PromoCell GmbH 10.4. Greiner Bio One International GmbH 10.5. Corning, Inc. 10.6. 3D Biomatrix 10.7. Lonza 10.8. Avantor Performance Materials, LLC 10.9. Tecan Trading AG 10.10. 3D Biotek LLC 10.11. Global Cell Solutions, Inc. 10.12. InSphero

About This Report

Report ID 337
Category Healthcare
Published Date July 2022
Updated Date
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