Digestive Diamine Oxidase Enzyme Supplements Market Size, Share, Industry Trends, Growth Drivers, Opportunities, Key Players Analysis, Regional Outlook and Forecast Report (2025–2032)

Digestive Diamine Oxidase Enzyme Supplements Market size was valued at USD 28.34 Million in 2024, and the total Digestive Diamine Oxidase Enzyme Supplements Market revenue is expected to grow at a CAGR of 5.96% from 2025 to 2032, reaching nearly USD 45.12 Million.
Digestive Diamine Oxidase Enzyme Supplements Market Overview:
The Digestive Diamine Oxidase Enzyme Supplements market revolves nearby a specialized dietary supplement that helps in the digestion of histamine-rich foods. Histamine intolerance, considered by an impaired ability to metabolize histamine owing to DAO deficiency, drives the demand for these supplements. DAO supplements are considered to support digestive health by breaking down histamine in the digestive tract, thus alleviating symptoms, for example, gastrointestinal discomfort, headaches, and skin reactions related to histamine intolerance.To know about the Research Methodology :- Request Free Sample Report

The market growth is driven by growing awareness of histamine intolerance, increasing prevalence of food sensitivities, and consumer preferences for natural digestive aids. Major players focus on product innovation, clinical validation, and consumer education to increase market penetration and cater to the growing consumer base seeking relief from histamine-related symptoms over dietary interventions.
Digestive Diamine Oxidase Enzyme Supplements Market Trends:
Scientific Advancements Drive Innovation in DAO Supplementation:
The market is witnessing a significant uptick in research and clinical studies, largely driven by increasing awareness of histamine intolerance and its impact on digestive health. As consumers become more proactive in managing gastrointestinal discomfort related to histamine accumulation, the demand for enzyme-based solutions, for example DAO, is increasing. In response, key players are placing greater prominence on scientific validation, investing in robust research efforts to establish credibility and efficacy.

In November 2024, nearly 515,000 clinical trials had been registered globally—a notable increase that underscores a broader movement toward evidence-based product growth within the nutraceutical and dietary supplement sectors. This surge in research activity reflects the industry's dedication to estimating the safety, effectiveness, and long-term benefits of DAO supplementation. Key areas of focus include the enzyme’s ability to degrade excess histamine in the gut, helping to relieve symptoms, for instance, headaches, bloating, and skin irritations.
E-Commerce and Retail Development Drive DAO Supplement Growth:
The market is undergoing a notable shift with the rapid growth of distribution channels. Once confined mostly to specialty health stores or distributed directly through healthcare practitioners, DAO supplements are now increasingly nearby through a broad array of platforms, including e-commerce websites, wellness clinics, retail pharmacies, and major retail chains. This transformation is being driven by growing consumer awareness of gut health, demand for convenient solutions, and the increasing influence of digital commerce.

E-commerce has emerged as a dominant channel, with global online dietary supplement sales expected to surpass US$ 60 Bn by 2025. The online environment allows consumers to explore a broader selection of DAO products, evaluate formulations, and make informed choices based on reviews and product transparency. Moreover, the growth of subscription-based services and personalized supplement regimens is helping to embed DAO enzymes more seamlessly into daily wellness routines, further strengthening the market presence.
Digestive Diamine Oxidase Enzyme Supplements Market Drivers:
The primary driver of the market is the increasing awareness of histamine intolerance and its related symptoms. As understanding of this condition rises, more individuals are identifying that symptoms, for example, digestive discomfort, headaches, and skin irritation, may stem from raised histamine levels that the body struggles to break down effectively. This has led to a notable increase in demand for DAO supplements, which help mitigate histamine-related issues. The awareness surge has been improved by online health communities, social media influencers, and proactive healthcare professionals who continue to educate the public on the role of DAO in managing histamine intolerance. In line with worldwide trends toward health consciousness, various consumers are increasingly opting for natural, enzyme-based solutions over conventional pharmaceuticals, further driving DAO supplement adoption.

Pharmaceutical companies are investing in clinical trials to explore DAO’s role in managing fibromyalgia, migraines, and chronic fatigue syndrome, conditions often related to histamine intolerance. As enzyme engineering continues to advance, DAO supplements and therapeutics are projected to become more potent, targeted, and nearby to a broader consumer base.

Another major market is the rising consumer preference for natural health products. Concerns over the side effects of synthetic drugs have driven interest in alternative remedies, with DAO supplements fitting well into this landscape as a naturally derived enzyme. Their supposed safety and alignment with holistic wellness approaches make them especially attractive. As per our analysis, the global market is expected to grow at a CAGR of 5.96% between 2025 and 2032, growth that is expected to further support the growth of DAO-based products within the broader supplement industry.
Digestive Diamine Oxidase Enzyme Supplements Market Challenges:
The market continues to face growth limitations due to low awareness among both consumers and healthcare professionals. While digestive health is gaining mainstream traction, histamine intolerance remains widely underdiagnosed and poorly understood. Various individuals suffer from symptoms such as headaches, bloating, and skin rashes without realizing the potential link to histamine buildup and DAO deficiency. A 2023 survey published in the World Journal of Gastroenterology revealed that fewer than 10% of general practitioners were aware of DAO deficiency as a contributing factor to gastrointestinal issues.

Consumer familiarity is likewise lacking. A 2023 survey conducted across Europe and North America revealed that only 12% of respondents had heard of DAO supplements or understood their role in managing histamine-related digestive issues. This limited public knowledge slows product adoption and hinders the market growth, particularly in regions where education around nutraceuticals is still emerging. The absence of DAO in standard diagnostic protocols and clinical guidelines further hampers integration into conventional healthcare practices. Addressing this challenge requires targeted educational initiatives for medical professionals, the integration of DAO research into academic curricula, and the broader dissemination of clinical evidence.

On the consumer side, awareness-building efforts over digital marketing, influencer engagement, transparent product labelling, and partnerships with wellness professionals can help bridge the knowledge gap. Younger health-conscious demographics, for example, millennials and Gen Z, present significant opportunities for targeted outreach. From a regulatory perspective, clearer classification of DAO supplements as functional foods or nutraceuticals will improve legitimacy and support market reliability.
Digestive Diamine Oxidase Enzyme Supplements Market Segment Analysis:
In 2024, the Capsules type is the dominant segment, holding around 67.84% of the market. This growth is driven by the widespread encapsulation of plant extracts, essential oils, and other natural substances, which has made capsule formulations the standard for many nutraceutical and herbal supplements.

Capsules are highly effective in preserving the integrity & bioactivity of sensitive ingredients, confirming product stability and efficacy. In addition to their functional benefits, capsules are favoured by consumers for their ease of ingestion. They provide flexibility, as they can be taken with or without food, making them a convenient choice for daily supplementation.

Furthermore, both pharmaceutical and dietary supplement manufacturers are increasingly adopting capsule formats owing to their versatility, dosage accuracy, and consumer preference. These factors collectively reinforce the capsule segment’s worldwide leadership within the diamine oxidase enzyme supplements market.

The hospitals segment accounted for the highest revenue share in the market in 2024. This dominance is driven by hospitals being the primary centres for diagnosing and treating conditions like mast cell activation syndrome (MCAS) and histamine intolerance, both of which often require DAO supplementation as part of their management.

Hospitals are uniquely placed to deliver specialized care, with the administration of DAO supplements by intravenous (IV) or high-dose oral formulations under medical supervision. Their access to diagnostic resources, clinical expertise, and personalized treatment protocols makes them a critical channel for DAO-based therapeutic interventions.
Recent Developments in Digestive Diamine Oxidase Enzyme Supplements Market:
Leading companies in the market were focusing on research and development to innovate new products or improve existing ones. This could involve developing digestive diamine oxidase enzyme supplements derivatives with enhanced properties or applications to cater to specific industry needs.



Year
Description


In July 2024
Global life sciences company Bioiberica has broadened its product portfolio with the launch of two new branded ingredients: DAOgest, designed to support digestive health by facilitating the breakdown of dietary histamine, and Dermial, formulated for skin and beauty applications. These product introductions underscore Bioiberica’s commitment to meeting rising consumer demand for specialized health and wellness solutions.


In June 2024
NEXGEL and STADA publicised a strategic partnership to launch Histasolv, a foremost European DAO enzyme supplement, in the North American market. This collaboration goals to address rising consumer demand for histamine intolerance solutions by introducing a clinically supported, high-quality digestive health product to a broader audience across the U.S. and Canada.


In April 2024
AB Biotek announced adiDAO Microencapsulated, a novel ingredient format designed to boost the delivery of diamine oxidase (DAO), an enzyme that breaks down dietary histamine. This invention also allows, for the first time, the integration of DAO with other functional ingredients in a single formulation.



Digestive Diamine Oxidase Enzyme Supplements Market Regional Analysis:
In 2024, North America dominated the global market with a 37.92% share. The demand for natural supplements that target dietary sensitivities or disorders has increased owing to the growing interest that North American society has in health and wellness. Similarly, the market for supplements that target symptom management may increase as more people become aware of histamine-related illnesses and food triggers. Further, the U.S. market held the largest market share in 2024, and the Canada market was the fastest growing market in the North America region during 2025-2032.

Europe's digestive diamine oxidase enzyme supplements market accounts for the second-largest market share in 2024. The demand for DAO enzyme supplements may be influenced by the long history of paying for natural treatments and supplements as supplementary therapies in some European countries. Moreover, Europe has a strong emphasis on wellness trends and holistic health practices, which are in line with the usage of natural supplements for symptom control. Further, the German digestive diamine oxidase enzyme supplements market held the largest market share, and the UK digestive diamine oxidase enzyme supplements market was the fastest-growing market in the European region.

The Asia-Pacific digestive diamine oxidase enzyme supplements market is expected to grow at the fastest CAGR of 6.12% from 2025 to 2032. Fermented foods are frequently used in the region's cuisine, which may rise histamine intake and create a market for supplements containing the DAO enzyme. Furthermore, growing interest in specialized supplements may result from the adoption of Western dietary practices and growing health consciousness. Furthermore, China’s digestive diamine oxidase enzyme supplements market held the largest market share, and the Indian digestive diamine oxidase enzyme supplements market was the fastest-growing market in the Asia-Pacific region.
Digestive Diamine Oxidase Enzyme Supplements Market Scope: Inquire before buying



Global Digestive Diamine Oxidase Enzyme Supplements Market


Report Coverage
Details


Base Year:
2024
Forecast Period:
2025-2032


Historical Data:
2019 to 2024
Market Size in 2024:
USD 28.34 Mn.


Forecast Period 2025 to 2032 CAGR:
5.96%
Market Size in 2032:
USD 45.12 Mn.


 Segments Covered:
by Type
Capsules
Tablets


by Application
Hospitals
Homecare
Specialty Clinics



Heat Transfer Fluids Market by Region
North America (United States, Canada, and Mexico)
Europe (UK, France, Germany, Italy, Spain, Sweden, Austria, and the Rest of Europe)
Asia Pacific (China, South Korea, Japan, India, Australia, Indonesia, Philippines, Malaysia, Vietnam, Thailand, and Rest of APAC)
Middle East & Africa (South Africa, GCC, Nigeria, Rest of ME&A)
South America (Brazil, Argentina, Rest of South America)
Digestive Diamine Oxidase Enzyme Supplements Market Key players:
1. DR Healthcare / ABbiotek Health
2. Bioiberica S.A.U.
3. Shaanxi Lonier Herb Bio Technology Co., Ltd.
4. Henan Fengda Chemical Co., Ltd.
5. Sigma-Aldrich
6. NaturDAO
7. Solaray
8. Pure Encapsulations
9. XYMOGEN
10. Biogena GmbH & Co KG
11. Seeking Health
12. Umbrellux DAO
13. Intolerant
14. OmneDiem
15. STADA Arzneimittel AG (DAOSIN®)
16. Enzymedica
17. Jarrow Formulas
18. NOW Foods
19. Swanson Health Products
20. Thompson's (Integria Healthcare)
21. Others
FAQs:
1. What are the growth drivers for the Digestive Diamine Oxidase Enzyme Supplements Market?
Ans. Growth drivers for the Digestive Diamine Oxidase Enzyme Supplements Market include rising awareness of histamine intolerance, increased preference for natural health solutions, and growing clinical research supporting DAO efficacy.

2. What is the major opportunity for the Digestive Diamine Oxidase Enzyme Supplements Market growth?
Ans. A major opportunity for market growth lies in expanding consumer and physician education, especially in emerging regions, alongside broader integration of DAO supplements into mainstream healthcare and wellness practices.

3. Which region is expected to lead the global Digestive Diamine Oxidase Enzyme Supplements Market during the forecast period?
Ans. North America is expected to lead the Digestive Diamine Oxidase Enzyme Supplements Market during the forecast period.

4. What is the projected market size and growth rate of the Digestive Diamine Oxidase Enzyme Supplements Market?
Ans. The Digestive Diamine Oxidase Enzyme Supplements Market size was valued at USD 28.34 Million in 2024, and the total Digestive Diamine Oxidase Enzyme Supplements Market revenue is expected to grow at a CAGR of 5.96% from 2025 to 2032, reaching nearly USD 45.12 Million.

5. What segments are covered in the Digestive Diamine Oxidase Enzyme Supplements Market report?
Ans. The segments covered in the Digestive Diamine Oxidase Enzyme Supplements Market report are by Type, Applications, and Region.