Global Synthetic siRNA Market : Industry Analysis and Forecast (2020-2026) By Tools and Applications and Region.

Global Synthetic siRNA Market is expected to reach US$ 3.5 Bn. at a CAGR of 10.1 during the forecast period 2026.

Global Synthetic siRNA Market: Overview

Synthetic siRNA are also known as short interfering RNA, which is a type of non-coding double stranded RNA of 20-23 nucleotide base pairs in length. It is a powerful tool used for modulating gene expression by RNA interference (RNAi).siRNAs consist of two RNA strands, an antisense (or guide) strand and a sense (or passenger) strand, which form a duplex 19 to 25 bp in length with 3' dinucleotide overhangs. siRNA are transfected into cells by using delivery methods like polymer-based transfection reagents, electroporation or by adding chemical modifications.

Global Synthetic siRNA Market Dynamics

Increasing applications in gene therapy is the major factor driving the market. Gene therapy offers a promising therapeutic platform as it targets disease-causing genes in a sequence-specific manner, which enables more precise and personalized treatment of diverse life-threatening diseases. Global prevalence of chronic diseases like cancer is noticing increasing number of applications in molecular diagnostics and incorporation of RNAi techniques in personalized medicines. Other advantages of siRNA include the high efficiency of the gene knockdown, the ability to easily target the gene of interest, as well as stable and long-term silencing by expressing shRNAs are accelerating the market growth. However, many challenges related to siRNA may limit the market growth. One of the biggest challenge to siRNA based therapeutics is its intracellular delivery, as it has weak stability and pharmacokinetic behavior. It also faces problem of off-targeting during delivery since genes are read in both directions, there exists a possibility that even if the intended antisense siRNA strand is read and knocks out the target mRNA, the sense siRNA strand may target another protein involved in another function. In recent years, there has been a decline in FDA drug approval rates. Getting FDA approval for a new drug has become extremely challenging. It approved less than half the number of new drugs in 2016 (19 so far) when compared to 2015 (45 total).Along with this, high cost of synthesis of required siRNA may hamper the market growth. The report has profiled key players in the market from different regions. However, the report has considered all market leaders, followers, and new entrants with investors while analyzing the market and estimation the size of the same. Increasing R&D activities in each region are different and focus is given on the regional impact on the cost, availability of advanced technology are analyzed.

Global Synthetic siRNA Market Segment Analysis:

The Global Synthetic siRNA Market is segmented based on the tools and applications. Based on applications, the oncology segment is expected to hold larger market share of XX% in 2019. According to the WHO, cancer is the second leading cause of death globally. Approximately 70% of deaths from cancer occur in low- and middle-income countries. Cancer-causing infections, such as hepatitis and human papillomavirus (HPV), are responsible for approximately 30% of cancer cases in low- and lower-middle-income countries. High-risk human papillomaviruses infect skin and mucosa, causing approximately 5% of cancers worldwide. The selected siRNA prevents the tumor from growing via RNAi to decrease expression of the M2 subunit of R2 (ribonucleotide reductase). Global Synthetic siRNA Market1 To Know About The Research Methodology :- Request Free Sample Report

Global Synthetic siRNA Market Regional Insights:

Regional Insights North America dominates the global market and is expected to continue the dominance throughout the forecast period. The US leads the global market owing to huge number of RNAi therapeutics in the development stage. High investments from biotechnology companies for the development of novel therapeutics is contributing to the market growth in the region. Rising prevalence of personalized medicines for life threatening diseases like cancer, HIV drives the demand for Synthetic siRNA market. For instance, AstraZeneca's agreement with Ionis pharmaceuticals is one of the big deals that are investing heavily into RNA-interference technology. According to the news released on 10th August 2018, the US Food and Drug Administration approved Onpattro (patisiran) infusion for the treatment of polyneuropathy. Recently, the FDA-approved GIVLAARI (givosiran, ALN-AS1) for the treatment of adults with acute hepatic porphyria (AHP). The report also helps in understanding Global Synthetic siRNA Market dynamics, structure by analyzing the market segments and project the Global Synthetic siRNA Market size. Clear representation of competitive analysis of key players by product, price, financial position, product portfolio, growth strategies, and regional presence in the Global Synthetic siRNA Market make the report investor’s guide.

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Global Synthetic siRNA Market2

Global Synthetic siRNA Market, by Region:

• North America • Europe • South America • MEA • APAC

Key players operating in Global Synthetic siRNA Market:

• Thermo Fisher Scientific Inc. • Bioneer • Dharmacon (ThermoFisher) • Invitrogen • Integrated DNA Technologies • MWG Biotech • OligoEngine • Proligo (Sigma) • Qiagen • AstraZeneca • Ionis pharmaceuticals • Alnylam Pharmaceuticals • Arcturus Therapeutics • Dicerna Pharmaceuticals • Merck & Co. Inc. (Sigma Aldrich)

Global Synthetic siRNA Market

1. Preface 1.1. Market Definition and Key Research Objectives 1.2. Research Highlights 2. Assumptions and Research Methodology 2.1. Report Assumptions 2.2. Abbreviations 2.3. Research Methodology 2.3.1. Secondary Research 2.3.1.1. Secondary data 2.3.1.2. Secondary Sources 2.3.2. Primary Research 2.3.2.1. Data from Primary Sources 2.3.2.2. Breakdown of Primary Sources 3. Executive Summary: Global Synthetic siRNA Market Size, by Market Value (US$ Mn) 3.1. Global Market Segmentation 3.2. Global Market Segmentation Share Analysis, 2019 3.2.1. Global 3.2.2. By Region (North America, Europe, Asia Pacific, South America, Middle East Africa) 3.3. Geographical Snapshot of the Synthetic siRNA Market 3.4. Geographical Snapshot of the Synthetic siRNA Market, By Manufacturer share 4. Global Synthetic siRNA Market Overview, 2019-2026 4.1. Market Dynamics 4.1.1. Drivers 4.1.1.1. Global 4.1.1.2. By Region (North America, Europe, Asia Pacific, South America, Middle East Africa) 4.1.2. Restraints 4.1.2.1. Global 4.1.2.2. By Region (North America, Europe, Asia Pacific, South America, Middle East Africa) 4.1.3. Opportunities 4.1.3.1. Global 4.1.3.2. By Region (North America, Europe, Asia Pacific, South America, Middle East Africa) 4.1.4. Challenges 4.1.4.1. Global 4.1.4.2. By Region (North America, Europe, Asia Pacific, South America, Middle East Africa) 4.1.5. Industry Trends and Emerging Technologies 4.1.6. Porters Five Forces Analysis 4.1.6.1. Threat of New Entrants 4.1.6.2. Bargaining Power of Buyers/Consumers 4.1.6.3. Bargaining Power of Suppliers 4.1.6.4. Threat of Substitute Products 4.1.6.5. Intensity of Competitive Rivalry 4.1.7. Value Chain Analysis 4.1.8. Technological Roadmap 4.1.9. Regulatory landscape 4.1.10. Impact of the Covid-19 Pandemic on the Global Synthetic siRNA Market 5. Supply Side and Demand Side Indicators 6. Global Synthetic siRNA Market Analysis and Forecast, 2019-2026 6.1. Global Synthetic siRNA Market Size & Y-o-Y Growth Analysis. 7. Global Synthetic siRNA Market Analysis and Forecasts, 2019-2026 7.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 7.1.1. Libraries 7.1.2. Software 7.1.3. Vectors 7.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 7.2.1. Oncology 7.2.2. Hepatitis 7.2.3. HIV infection 8. Global Synthetic siRNA Market Analysis and Forecasts, By Region 8.1. Market Size (Value) Estimates & Forecast By Region, 2019-2026 8.1.1. North America 8.1.2. Europe 8.1.3. Asia-Pacific 8.1.4. Middle East & Africa 8.1.5. South America 9. North America Synthetic siRNA Market Analysis and Forecasts, 2019-2026 9.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 9.1.1. Libraries 9.1.2. Software 9.1.3. Vectors 9.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 9.2.1. Oncology 9.2.2. Hepatitis 9.2.3. HIV infection 10. North America Synthetic siRNA Market Analysis and Forecasts, By Country 10.1. Market Size (Value) Estimates & Forecast By Country, 2019-2026 10.1.1. US 10.1.2. Canada 10.1.3. Mexico 11. U.S. Synthetic siRNA Market Analysis and Forecasts, 2019-2026 11.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 11.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 12. Canada Synthetic siRNA Market Analysis and Forecasts, 2019-2026 12.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 12.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 13. Mexico Synthetic siRNA Market Analysis and Forecasts, 2019-2026 13.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 13.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 14. Europe Synthetic siRNA Market Analysis and Forecasts, 2019-2026 14.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 14.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 15. Europe Synthetic siRNA Market Analysis and Forecasts, By Country 15.1. Market Size (Value) Estimates & Forecast By Country, 2019-2026 15.1.1. U.K 15.1.2. France 15.1.3. Germany 15.1.4. Italy 15.1.5. Spain 15.1.6. Sweden 15.1.7. CIS Countries 15.1.8. Rest of Europe 16. U.K. Synthetic siRNA Market Analysis and Forecasts, 2019-2026 16.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 16.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 17. France Synthetic siRNA Market Analysis and Forecasts, 2019-2026 17.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 17.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 18. Germany Synthetic siRNA Market Analysis and Forecasts, 2019-2026 18.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 18.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 19. Italy Synthetic siRNA Market Analysis and Forecasts, 2019-2026 19.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 19.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 20. Spain Synthetic siRNA Market Analysis and Forecasts, 2019-2026 20.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 20.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 21. Sweden Synthetic siRNA Market Analysis and Forecasts, 2019-2026 21.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 21.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 22. CIS Countries Synthetic siRNA Market Analysis and Forecasts, 2019-2026 22.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 22.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 23. Rest of Europe Synthetic siRNA Market Analysis and Forecasts, 2019-2026 23.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 23.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 24. Asia Pacific Synthetic siRNA Market Analysis and Forecasts, 2019-2026 24.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 24.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 25. Asia Pacific Synthetic siRNA Market Analysis and Forecasts, by Country 25.1. Market Size (Value) Estimates & Forecast By Country, 2019-2026 25.1.1. China 25.1.2. India 25.1.3. Japan 25.1.4. South Korea 25.1.5. Australia 25.1.6. ASEAN 25.1.7. Rest of Asia Pacific 26. China Synthetic siRNA Market Analysis and Forecasts, 2019-2026 26.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 26.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 27. India Synthetic siRNA Market Analysis and Forecasts, 2019-2026 27.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 27.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 28. Japan Synthetic siRNA Market Analysis and Forecasts, 2019-2026 28.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 28.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 29. South Korea Synthetic siRNA Market Analysis and Forecasts, 2019-2026 29.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 29.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 30. Australia Synthetic siRNA Market Analysis and Forecasts, 2019-2026 30.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 30.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 31. ASEAN Synthetic siRNA Market Analysis and Forecasts, 2019-2026 31.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 31.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 32. Rest of Asia Pacific Synthetic siRNA Market Analysis and Forecasts, 2019-2026 32.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 32.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 33. Middle East Africa Synthetic siRNA Market Analysis and Forecasts, 2019-2026 33.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 33.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 34. Middle East Africa Synthetic siRNA Market Analysis and Forecasts, by Country 34.1. Market Size (Value) Estimates & Forecast by Country, 2019-2026 34.1.1. South Africa 34.1.2. GCC Countries 34.1.3. Egypt 34.1.4. Nigeria 34.1.5. Rest of ME&A 35. South Africa Synthetic siRNA Market Analysis and Forecasts, 2019-2026 35.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 35.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 36. GCC Countries Synthetic siRNA Market Analysis and Forecasts, 2019-2026 36.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 36.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 37. Egypt Synthetic siRNA Market Analysis and Forecasts, 2019-2026 37.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 37.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 38. Nigeria Synthetic siRNA Market Analysis and Forecasts, 2019-2026 38.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 38.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 39. Rest of ME&A Synthetic siRNA Market Analysis and Forecasts, 2019-2026 39.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 39.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 40. South America Synthetic siRNA Market Analysis and Forecasts, 2019-2026 40.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 40.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 41. South America Synthetic siRNA Market Analysis and Forecasts, by Country 41.1. Market Size (Value) Estimates & Forecast by Country, 2019-2026 41.1.1. Brazil 41.1.2. Argentina 41.1.3. Rest of South America 42. Brazil Synthetic siRNA Market Analysis and Forecasts, 2019-2026 42.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 42.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 43. Argentina Synthetic siRNA Market Analysis and Forecasts, 2019-2026 43.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 43.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 44. Rest of South America Synthetic siRNA Market Analysis and Forecasts, 2019-2026 44.1. Market Size (Value) Estimates & Forecast By Tools, 2019-2026 44.2. Market Size (Value) Estimates & Forecast By Application, 2019-2026 45. Competitive Landscape 45.1. Geographic Footprint of Major Players in the Global Synthetic siRNA Market 45.2. Competition Matrix 45.2.1. Competitive Benchmarking of key players by price, presence, market share, Applications and R&D investment 45.2.2. New Product Launches and Product Enhancements 45.2.3. Market Consolidation 45.2.3.1. M&A by Regions, Investment and Applications 45.2.3.2. M&A Key Players, Forward Integration and Backward Integration 45.3. Company Profile - Thermo Fisher Scientific Inc. 45.3.1. Company Overview 45.3.2. Financial Overview 45.3.3. Geographic Footprint 45.3.4. Product Portfolio 45.3.5. Business Strategy 45.3.6. Recent Developments 45.4. Bioneer 45.5. Dharmacon (ThermoFisher) 45.6. Invitrogen 45.7. Integrated DNA Technologies 45.8. MWG Biotech 45.9. OligoEngine 45.10. Proligo (Sigma) 45.11. Qiagen 45.12. AstraZeneca 45.13. Ionis pharmaceuticals 45.14. Alnylam Pharmaceuticals 45.15. Arcturus Therapeutics 45.16. Dicerna Pharmaceuticals 45.17. Merck & Co. Inc. (Sigma Aldrich) 45.18. Others 46. Primary Key Insights
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