Enzyme Replacement Therapy Market size was valued at US$ 8.09 Bn in 2022 and the total revenue is expected to grow at 5.81% through 2023 to 2029, reaching nearly US$ 12.01 Bn.Enzyme Replacement Therapy Market Overview:
Enzyme Replacement Therapy (ERT) is a type of drug that is used to treat rare diseases and is referred to as an orphan drug. Pancreatic enzyme replacement therapy is a safe and effective treatment for patients with pancreatic exocrine insufficiency. In Fabry’s's disease with agalsidase beta, enzyme replacement therapy improves cardiac involvement and also aids kidney transplantation. The rising prevalence of rare diseases, combined with technological advancements, is propelling this market forward. Increased research and development activities are also expected to boost overall market demand for Enzyme Replacement Therapy. ERT replacement patients always suffering from the enzyme deficiency is the method of replacing artificial enzymeTo know about the Research Methodology :- Request Free Sample Report
Enzyme Replacement Therapy Market Dynamics:
Increasing prevalence of rare disease increases the Enzyme Replacement Therapy Market. According to Genetic and Rare Disease Information Center, about 200,000 individual are affected by rare disease are increasing the Growth of Enzyme Replacement Therapy Market over the forecast period 2023-2029.This rare disease also called as Orphan Disease are the major driving factor for the Enzyme Replacement Therapy (ERT) market. The Orphan drug act 1983 is a U.S. public law that has been that has been crucial in development of Novel drug for the treatment of Tourette syndrome myoclonus, ALS, muscular dystrophy, and Huntington's disease. After the approval of these act several region such as Australia, Japan and European Union followed suit to facilitate the enhanced treatment for the orphan disease, propelling the growth of the Enzyme Replacement Therapy Market. Growing technological advancement and developing innovative therapies with increasing use of recombinant DNA technology are increases the growth of market. According to estimates from Genetic Alliance UK, a Single rare disease is affected over 30,000 individual in UK. As majority of chronic disease are life threatening, timely medical treatment is very important to decrease mortality rates. Rare disease are occur in less frequencies in the people. For example according to Orphanet Gaucher’s disease is estimated to prevalent in 1 individual over 100,000 individuals. The low prevalence of orphan and rare disease are the key factor for restrict the growth of Enzyme Replacement Therapy Market. The factors that impede the growth of Enzyme Replacement Therapy market are high cost of treatment, availability of option treatment and lack of skill of healthcare professionals are set to create hurdle for the Enzyme Replacement Therapy Market. In 2019 Takeda pharmaceutical has acquisition with the Shire, this acquisition help to expand product portfolio of rare disease treatmentEnzyme Replacement Therapy Market Segment Analysis:
The Enzyme Replacement Therapy Market is segmented By Therapeutic Condition, Application, and End-User. Based on the Therapeutic Condition, the Enzyme Replacement Therapy Market is segmented into Bifurcated Pompe’s Disease, Gaucher’s disease, Fabry’s Disease, SCID and MPS. Gaucher’s disease segment is major segment which generating high revenue in 2020.This is owing to prevalence of increasing Gaucher’s disease condition in people and according to National Gaucher’s foundation Gaucher’s disease can occur up to 1 in 40,000 births globally which increases the demand of Enzyme Replacement Therapy and the high growth of this segment. The Fabry’s disease segment is estimated to register the faster CAGR of 3.8% for the period of 2023 -2029.This is because of rapidly increasing demand of agaldidase beta base enzyme replacement therapies which is only used for Fabry’s Disease. According to statistics from the U.S. National Library of medicine the disease is estimated to occur in one individual in 50,000 to 100,000 individuals of general population. Based on the Route of Administration, the Enzyme Replacement Therapy Market based on route of administration is further segmented into the Oral Route and Parenteral Route. The Parenteral route is accounted for the highest market share of 47% in the year 2022.This is because of its ability to facilitate rapid absorption, fast drug delivery and provides convenient storage this factors enhanced the growth of this segment. Oral segment estimated to register the growing CAGR of 3.7% during the forecast period. This is owing to ease of ingestion, pain and safety contributed into the Market.Based on the End User, The Enzyme Replacement Therapy Market is segmented into the Hospital, Infusion Center and Others. Hospital are primary care setting, facilitating wide range of disease. These segment held the largest market share, owing to frequent visits by patients for the services and facilities in the hospital. Infusion Center held the highest CAGR of 38% in the year 2022.Thse center are specialized center for the IV infusion, they facilitate the easy treatment for the wide range of disease.
Enzyme Replacement Therapy Market Regional Insights:
North America dominated the Enzyme Replacement Therapy market with the largest market share of 42% in 2022. This is because adoption of advanced technologies and focusing on research and development process. According to National Organization of Rare Disease in 2019, 6000 individuals were suffered from Gaucher’s disease in U.S. that increases the demand for Enzyme Replacement Therapy and increasing the growth of this market. Asia Pacific estimated the highest CAGR of 25% during the forecast period because of innovative technologies and rising the healthcare facilities globally. Europe region accounted for the second highest revenue and expected to grow with the CAGR of 7.4%.The healthcare system in Europe is publicly funded and other countries have adopted universal healthcare system. According to statistics from Fabry’s outcome survey prepared by Shire outcome survey Germany, Japan and UK exhibit the highest incidence of Fabry’s disease. Data from FDA novel drug approval indicate that over 40% of drug approved in the year 2019 were for the Orphan disease. Asia pacific region consist of developed as well as developing countries like India, China and others. Most of the countries in this region is economically developing and the disposal income is gradually increasing. Many multinational companies are heavily investing in this region. The objective of the report is to present a comprehensive analysis of the Enzyme Replacement Therapy Market to the stakeholders in the industry. The past and current status of the industry with the forecasted market size and trends are presented in the report with the analysis of complicated data in simple language. The report covers all the aspects of the industry with a dedicated study of key players that include market leaders, followers, and new entrants. PORTER, PESTEL analysis with the potential impact of micro-economic factors of the market have been presented in the report. External as well as internal factors that are supposed to affect the business positively or negatively have been analyzed, which will give a clear futuristic view of the industry to the decision-makers. The reports also helps in understanding the Market dynamic, structure by analyzing the market segments and project the Market size. Clear representation of competitive analysis of key players by product, price, financial position, product portfolio, growth strategies, and regional presence in the Enzyme Replacement Therapy Market make the report investor’s guide.Enzyme Replacement Therapy Market Scope: Inquire before buying
Enzyme Replacement Therapy Market Report Coverage Details Base Year: 2022 Forecast Period: 2023-2029 Historical Data: 2018 to 2022 Market Size in 2022: US $ 8.09 Bn. Forecast Period 2023 to 2029 CAGR: 5.81% Market Size in 2029: US $ 12.01 Bn. Segments Covered: by Therapeutic Condition Bifurcated Pompe’s Disease Gaucher’s Disease Fabry’s Disease SCID MPS by Route Of Administration Oral Parenteral by End-User Hospital Infusion Center Other Enzyme Replacement Therapy Market, by Region
North America (United States, Canada and Mexico) Europe (UK, France, Germany, Italy, Spain, Sweden, Austria and Rest of Europe) Asia Pacific (China, South Korea, Japan, India, Australia, Indonesia, Malaysia, Vietnam, Taiwan, Bangladesh, Pakistan and Rest of APAC) Middle East and Africa (South Africa, GCC, Egypt, Nigeria and Rest of ME&A) South America (Brazil, Argentina Rest of South America)Enzyme Replacement Therapy Market Key Players
1. Shire Plc 2. Biomarin Pharmaceutical Inc. 3. AbbVie 4. Alexion Pharmaceuticals Inc. 5. Allergan plc 6. Horizon Pharma Public Limited Company 7. Actelion (Janssen) 8. Recordati Rare Diseases 9. Protalix Biotherapeutics 10.Amicus Therapeutics, Inc. 11.Pfizer 12.Leadiant Biosciences 13.Johnson and Johnson 14.Recordati Rare Diseases 15.Sanofi 16.Digestive CareFrequently Asked Questions:
1] Which segments are covered in Enzyme Replacement Therapy Market report? Ans. The segments covered in Market report are based on Therapeutic Condition, Route of Administration and End-User. 2] Which region is expected to hold the highest share in the Enzyme Replacement Therapy Market? Ans. North America is expected to hold the highest share in the Market. 3] What is the market size of Market by 2029? Ans. The market size of Market by 2029 is US $ 12.01 Bn. 4] Who are the top key players in the Market? Ans. Shire Plc; Sanofi S.A., Biomarin Pharmaceutical Inc., AbbVie, Alexion Pharmaceuticals Inc., Allergan plc, Horizon Pharma Public Limited Company, Actelion (Janssen), Recordati Rare Diseases, Protalix Biotherapeutics, Amicus Therapeutics, Inc., Actelion, Pfizer, Leadiant Biosciences, Horizon Pharma, Allergan, BioMarin are the top key players in the Market. 5] What was the market size of Market in 2022? Ans. The market size of Market in 2022 was US $ 8.09 Bn.
1. Preface 1.1. Market Definition and Key Research Objectives 1.2. Research Highlights 2. Assumptions and Research Methodology 2.1. Report Assumptions 2.2. Abbreviations 2.3. Research Methodology 2.3.1. Secondary Research 2.3.1.1. Secondary data 2.3.1.2. Secondary Sources 2.3.2. Primary Research 2.3.2.1. Data from Primary Sources 2.3.2.2. Breakdown of Primary Sources 3. Executive Summary: Enzyme Replacement Therapy Market Size, by Market Value (US$ Bn) 3.1. Global Market Segmentation 3.2. Global Market Segmentation Share Analysis, 2022 3.2.1. Global 3.2.2. By Region (North America, Europe, Asia Pacific, South America, Middle East Africa) 3.3. Geographical Snapshot of the Enzyme Replacement Therapy Market 3.4. Geographical Snapshot of the Enzyme Replacement Therapy Market , By Manufacturer share 4. Enzyme Replacement Therapy Market Overview, 2022-2029 4.1. Market Dynamics 4.1.1. Drivers 4.1.1.1. Global 4.1.1.2. By Region (North America, Europe, Asia Pacific, South America, Middle East Africa) 4.1.2. Restraints 4.1.2.1. Global 4.1.2.2. By Region (North America, Europe, Asia Pacific, South America, Middle East Africa) 4.1.3. Opportunities 4.1.3.1. Global 4.1.3.2. By Region (North America, Europe, Asia Pacific, South America, Middle East Africa) 4.1.4. Challenges 4.1.4.1. Global 4.1.4.2. By Region (North America, Europe, Asia Pacific, South America, Middle East Africa) 4.1.5. Industry Trends and Emerging Technologies 4.1.6. Porters Five Forces Analysis 4.1.6.1. Threat of New Entrants 4.1.6.2. Bargaining Power of Buyers/Consumers 4.1.6.3. Bargaining Power of Suppliers 4.1.6.4. Threat of Substitute Products 4.1.6.5. Intensity of Competitive Rivalry 4.1.7. Value Chain Analysis 4.1.8. Technological Roadmap 4.1.9. Regulatory landscape 4.1.10. Impact of the Covid-19 Pandemic on the Enzyme Replacement Therapy Market 5. Supply Side and Demand Side Indicators 6. Enzyme Replacement Therapy Market Analysis and Forecast, 2022-2029 6.1. Enzyme Replacement Therapy Market Size & Y-o-Y Growth Analysis. 7. Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 7.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 7.1.1. Bifurcated Pompe’s Disease 7.1.2. Gaucher’s Disease 7.1.3. Fabry’s Disease 7.1.4. SCID 7.1.5. MPS 7.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 7.2.1. Oral 7.2.2. Parenteral 7.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 7.3.1. Hospital 7.3.2. Infusion Center 7.3.3. Other 8. Enzyme Replacement Therapy Market Analysis and Forecasts, By Region 8.1. Market Size (Value) Estimates & Forecast By Region, 2022-2029 8.1.1. North America 8.1.2. Europe 8.1.3. Asia-Pacific 8.1.4. Middle East & Africa 8.1.5. South America 9. North America Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 9.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 9.1.1. Bifurcated Pompe’s Disease 9.1.2. Gaucher’s Disease 9.1.3. Fabry’s Disease 9.1.4. SCID 9.1.5. MPS 9.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 9.2.1. Oral 9.2.2. Parenteral 9.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 9.3.1. Hospital 9.3.2. Infusion Center 9.3.3. Other 10. North America Enzyme Replacement Therapy Market Analysis and Forecasts, By Country 10.1. Market Size (Value) Estimates & Forecast By Country, 2022-2029 10.1.1. US 10.1.2. Canada 10.1.3. Mexico 11. U.S. Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 11.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 11.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 11.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 12. Canada Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 12.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 12.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 12.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 13. Mexico Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 13.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 13.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 13.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 14. Europe Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 14.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 14.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 14.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 15. Europe Enzyme Replacement Therapy Market Analysis and Forecasts, By Country 15.1. Market Size (Value) Estimates & Forecast By Country, 2022-2029 15.1.1. U.K 15.1.2. France 15.1.3. Germany 15.1.4. Italy 15.1.5. Spain 15.1.6. Sweden 15.1.7. CIS Countries 15.1.8. Rest of Europe 16. U.K. Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 16.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 16.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 16.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 17. France Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 17.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 17.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 17.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 18. Germany Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 18.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 18.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 18.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 19. Italy Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 19.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 19.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 19.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 20. Spain Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 20.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 20.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 20.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 21. Sweden Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 21.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 21.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 21.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 22. CIS Countries Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 22.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 22.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 22.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 23. Rest of Europe Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 23.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 23.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 23.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 24. Asia Pacific Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 24.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 24.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 24.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 25. Asia Pacific Enzyme Replacement Therapy Market Analysis and Forecasts, by Country 25.1. Market Size (Value) Estimates &Forecast By Country, 2022-2029 25.1.1. China 25.1.2. India 25.1.3. Japan 25.1.4. South Korea 25.1.5. Australia 25.1.6. ASEAN 25.1.7. Rest of Asia Pacific 26. China Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 26.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 26.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 26.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 27. India Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 27.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 27.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 27.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 28. Japan Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 28.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 28.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 28.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 29. South Korea Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 29.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 29.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 29.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 30. Australia Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 30.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 30.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 30.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 31. ASEAN Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 31.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 31.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 31.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 32. Analysis and Forecasts, 2022-2029 32.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 32.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 32.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 33. Middle East Africa Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 33.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 33.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 33.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 34. Middle East Africa Enzyme Replacement Therapy Market Analysis and Forecasts, by Country 34.1. Market Size (Value) Estimates & Forecast by Country, 2022-2029 34.1.1. South Africa 34.1.2. GCC Countries 34.1.3. Egypt 34.1.4. Nigeria 34.1.5. Rest of ME&A 35. South Africa Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 35.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 35.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 35.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 36. GCC Countries Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 36.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 36.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 36.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 37. Egypt Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 37.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 37.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 37.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 38. Nigeria Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 38.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 38.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 38.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 39. Rest of ME&A Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 39.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 39.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 39.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 40. South America Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 40.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 40.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 40.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 41. South America Enzyme Replacement Therapy Market Analysis and Forecasts, by Country 41.1. Market Size (Value) Estimates & Forecast by Country, 2022-2029 41.1.1. Brazil 41.1.2. Argentina 41.1.3. Rest of South America 42. Brazil Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 42.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 42.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 42.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 43. Argentina Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 43.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 43.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 43.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 44. Rest of South America Enzyme Replacement Therapy Market Analysis and Forecasts, 2022-2029 44.1. Market Size (Value) Estimates & Forecast By Therapeutic Condition, 2022-2029 44.2. Market Size (Value) Estimates & Forecast By Route Of Administration, 2022-2029 44.3. Market Size (Value) Estimates & Forecast By End-User, 2022-2029 45. Competitive Landscape 45.1. Geographic Footprint of Major Players in the Enzyme Replacement Therapy Market 45.2. Competition Matrix 45.2.1. Competitive Benchmarking of Key Players By Price, Presence, Market Share, Applications and R&D Investment 45.2.2. New Product Launches and Product Enhancements 45.2.3. Market Consolidation 45.2.3.1. M&A by Regions, Investment and Verticals 45.2.3.2. M&A, Forward Integration and Backward Integration 45.2.3.3. Partnership, Joint Ventures and Strategic Alliances/ Sales Agreements 45.3. Company Profile : Key Players 45.3.1. Abbvie 45.3.1.1. Company Overview 45.3.1.2. Financial Overview 45.3.1.3. Geographic Footprint 45.3.1.4. Product Portfolio 45.3.1.5. Business Strategy 45.3.1.6. Recent Developments 45.3.2. Alexion Pharmaceuticals Inc. 45.3.3. Allergan plc 45.3.4. Horizon Pharma Public Limited Company 45.3.5. Actelion (Janssen) 45.3.6. Recordati Rare Diseases 45.3.7. Protalix Biotherapeutics 45.3.8. Amicus Therapeutics, Inc. 45.3.9. Actelion 45.3.10. Pfizer 45.3.11. Leadiant Biosciences 45.3.12. Horizon Pharma 45.3.13. Allergan 45.3.14. BioMarin 45.3.15. Shire 45.3.16. Johnson and Johnson 45.3.17. Recordati Rare Diseases 45.3.18. Sanofi 45.3.19. AbbVie 46. Primary Key Insights