L-Histidine Market Size, Share, Trends and Forecast Analysis (2025-2032)

L-Histidine Market size was valued at USD 704.33 Mn. in 2024 and the total Global L-Histidine Market revenue is expected to grow at a CAGR of 7.1% from 2025 to 2032, reaching nearly USD 1219.25 Mn. by 2032.
L-Histidine Market Overview
L-Histidine is an essential amino acid required for making proteins in the body. It is also involved in various important biological processes like protein synthesis, tissue repair and neurotransmitter regulation

L-Histidine Market has been growing by increasing demand from pharmaceutical manufacturers, nutraceutical formulators, clinical researcher and specialty food producers. Rising focus on amino acid-based therapies, immune system improvement and long lasting metabolic and neurological support is accelerating market adoption. Increasing application of L-histidine across parenteral nutrition, dietary supplements, enzyme co factor synthesis and metabolic disorder treatments are reshaping traditional health solutions and supporting rise of bio integrated formulations. Technological advancements like precision fermentation, bioengineered microbial synthesis, high purity amino acid extraction and AI assisted compound profiling are enhancing efficiency, safety and personalization of L-histidine production and utilization. Market is supported by rising healthcare and wellness expenditure, growing awareness of essential amino acid roles in aging populations and global shift toward preventive healthcare and functional nutrition. North America dominated L-histidine market in 2024, due to region’s advanced bioprocessing infrastructure, high R&D investments, growing clinical nutrition needs and established pharmaceutical supply chains. Key players in L-Histidine Market include Ajinomoto Co., Inc., Kyowa Hakko Bio Co., Ltd. and Evonik Industries AG. Companies are focusing on pharmaceutical grade L-histidine production, increasing amino acid based therapeutic portfolios, forming strategic collaboration and investing in safe, and scientifically validated amino acid innovation to meet growing global demand.

Report covers L-Histidine market dynamics, structure by analyzing market segments and projecting Global L-Histidine market size. Clear representation of competitive analysis of key players By Type, price, financial position, product portfolio, growth strategies and regional presence in Global L-Histidine market.To know about the Research Methodology :- Request Free Sample Report
L-Histidine Market Dynamics
Growing demand for the development of new drugs to boost the L-Histidine market

The pharmaceutical industry is witnessing growing need for the development of new drugs and therapies, driving the growth of the L-Histidine market. The growing incidence of conditions such as cardiovascular diseases, cancer, neurological disorders, and metabolic disorders is resulting in increased demand for innovative drugs and therapies that can effectively treat and manage these diseases. The technological advancement has opened new avenues for drug discovery and development. The understanding of molecular pathways, genetic factors, & mechanism of disease has improved, enabling researchers to identify new drug targets and develop more targeted and personalized treatment options utilizing L-histidine, thus driving industry potential during forecast period. There is a growing realization of different response to medication on individual basis based on their genetic makeup, lifestyle, and specific disease characteristics. The pharmaceutical companies are investing in research and development efforts to create drugs that are more effective and well-tolerated by patients. L-Histidine market has high potential in the personalized medicine sector.

Increasing demand for L-Histidine as dietary supplement is driving market growth

The global health and wellness industry has experienced significant growth, due to consumers becoming conscious of their diet. People are becoming more conscious of the nutrients they consume and are seeking ways to optimize their nutritional intake. L-histidine is known for potential health benefits, such as supporting muscle growth, promoting wound healing, and enhancing immune function, which makes it a preferred supplement choice for many individuals, driving the industry growth. L-histidine is included in sports nutrition products due to its role in muscle growth and repair. Athletes and fitness enthusiasts are keen on optimizing their performance and enhancing recovery, leading to a higher demand for L-histidine market.

L-histidine is directly linked with certain health conditions such as rheumatoid arthritis, allergic reactions, and ulcers. Individuals suffering from these conditions are prescribed L-histidine supplements as part of their treatment. The expanding aging population is further driving the L-histidine market. As people age, their nutritional needs change with a focus on maintaining overall health and well-being. L-histidine is known to support joint health, aid in the prevention of age-related muscle loss, and contribute to cognitive function, making it important for geriatric nutrition.
L-Histidine Market Segment Analysis
Based on Type, The L- Histidine market is segmented based on type into tablets, capsules, fluids, and other forms of L-Histidine. Tablets have emerged as the dominated segment in the L-Histidine market in 2024. Tablets offer convenience, ease of consumption, and accurate dosage, making them a preferred choice for consumers. They are widely available and can be easily taken with or without food, providing flexibility and accessibility to users. Capsules, fluids, and other forms also contribute to the market, catering to specific needs and preferences of consumers who may have different preferences or requirements. Fluid Segment expected to have significant growth in the L-Histidine market during the forecast period.

Fluids offer advantages such as ease of consumption and rapid absorption into the body, making them popular among consumers seeking quick and efficient delivery of L-Histidine. The growing recognition of the benefits of fluid-based L-Histidine, including ease of use and faster absorption, is expected to drive the segment growth during the forecast period. Manufacturers and suppliers in the industry are increasingly focusing on developing innovative fluid-based formulations to capitalize the huge potential in the segment during the forecast period.

Based on the Application, The L-Histidine market is segmented based on application into pharmaceutical industry, biotechnological industry, and medical industry. The pharmaceutical industry segment accounted for the highest share in the L-Histidine market in 2024. L-Histidine has extensive applications in the pharmaceutical sector owing to its therapeutic properties and its role in the synthesis of various drugs and pharmaceutical compounds. It is utilized in the formulation of medications for treating a wide range of health conditions, including allergies, asthma, rheumatoid arthritis, and digestive disorders. The Growing prevalence of chronic diseases and the continuous advancements in pharmaceutical research is increasing the demand for the segment.

The biotechnological industry segment is expected to have rapid growth in the L-histidine market during the forecast period. L-Histidine has extensive use in biotechnological research and development. It has application in areas such as cell culture, protein expression, genetic engineering, and enzyme production, driving the segment growth. The growing demand for biopharmaceuticals, personalized medicine, and advancements in genetic engineering techniques are driving the growth of the biotechnological industry. L-Histidine is contributing to the development of novel therapies, and biotechnological products & is expected witness huge potential during the forecast period in the biotechnology industry segment.
L-Histidine Market Regional Analysis
By Region, L-Histidine market is categorized into North America, Europe, Asia Pacific, and the Rest of the world based on regional analysis. North dominated the L-Histidine market in 2024. The region is dominating due to the strong presence and advancements in the medical, biopharmaceutical, and pharmaceutical industries. North America has a well-established healthcare infrastructure and has presence of numerous leading pharmaceutical companies, research institutions, & medical facilities. The region's focus on innovation and research and development activities has contributed to the growth of the L-Histidine market.

The medical, biopharmaceutical, and pharmaceutical industries in North America investments in drug development, clinical trials, and manufacturing processes. These industries prioritize the development of advanced therapeutic products, including drugs and supplements that incorporate L-Histidine. The demand for L-Histidine in these industries is driven by the increasing prevalence of various diseases and the need for effective treatments. North America has a high level of awareness and demand for healthcare products, including dietary supplements, contributing to the growth of the L-Histidine market. The population the region is getting increasingly drawn towards maintaining good health and incorporating nutritional supplements into their daily routines, further driving the demand for L-Histidine market in the region.

L-Histidine Market Competitive Landscape

Report covers 25 key players in L-Histidine market, including a strategic mix of market leaders, market challengers, market followers and niche players. Market leaders are Ajinomoto Co., Inc. and Kyowa Hakko Bio Co., Ltd. dominate global supply and amino acid innovation. Companies lead in pharmaceutical grade purity, clinical research partnerships and advanced fermentation technologies. Market challengers like Evonik Industries AG and CJ CheilJedang Corp. are investing heavily in sustainable L-histidine production and expanding reach in functional food, supplements and biopharmaceutical markets. Market followers such as Daesang Corporation and Pfanstiehl Inc. are offering reliable, cost-effective L-histidine ingredients for use in general nutrition, cell culture media and clinical nutrition targeting steady growth in mainstream applications. Niche players including Fufeng Group Ltd. and Vedan International Holdings Ltd. focus on specific production for food additives, animal nutrition and emerging personalized health products. Players deliver localized value through flexible manufacturing, affordability and region-specific regulatory alignment.

L-Histidine Market Trends

• Rising Demand Across Key Applications
Nutritional Supplements- With growing health consciousness and preventive healthcare uptake, L Histidine is increasingly included in immune-support, metabolic, and recovery formulations drive demand in the supplement space.

• Technological Innovation & Sustainability
Advances in fermentation and biotech-driven microbial production are enabling more efficient, clean, high purity L Histidine manufacturing.

• Evolving Distribution Channels
E Commerce Growth- Online retail continues to rise as a primary purchase route for food grade L Histidine supplements, due to convenience and competitive pricing.

L-Histidine Market Recent Development

• On May 2025, Kyowa Hakko Bio Co., Ltd. (Japan) entered a strategic collaboration with a biotech startup to develop next generation precision fermentation techniques for L histidine production, targeting higher efficiency and quality for pharmaceutical and nutraceutical applications.

• March 2025, Ajinomoto Co., Inc. (Japan) Launched a new L histidine supplement blend in Japan targeting immunity and joint health among aging populations reflecting its focus on innovative nutritional products tailored to demographic needs.
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L-Histidine Market


Report Coverage
Details


Base Year:
2024
Forecast Period:
2025-2032


Historical Data:
2019 to 2024
Market Size in 2024:
USD 704.33 Mn.


Forecast Period 2025 to 2032 CAGR:
7.1%
Market Size in 2032:
USD 1219.25 Mn.


 Segments Covered:
by Type
Tablet
Capsule
Fluids
Others


by Application
Pharmaceutical Industry,
Biotechnological Industry
Medical Industry



L-Histidine Market by Region
North America (United States, Canada and Mexico)
Europe (UK, France, Germany, Italy, Spain, Sweden, Austria and Rest of Europe)
Asia Pacific (China, South Korea, Japan, India, Australia, Indonesia, Malaysia, Vietnam, Taiwan, Bangladesh, Pakistan and Rest of APAC)
Middle East and Africa (South Africa, GCC, Egypt, Nigeria and Rest of ME&A)
South America (Brazil, Argentina Rest of South America)
L-Histidine Market Key Players
North America

1. Pfanstiehl Inc. (USA)
2. Spectrum Chemical Mfg. Corp. (USA)
3. Prinova Group LLC (USA)
4. Perque LLC (USA)
5. Nutraceutical Corporation (USA)
6. Bio-Techne Corporation (USA)
7. Jarrow Formulas Inc. (USA)
8. NOW Health Group, Inc. (USA)
9. Twinlab Consolidation Corporation (USA)

Europe

10. Evonik Industries AG (Germany)
11. BASF SE (Germany)
12. Merck KGaA (Germany)
13. Lonza Group AG (Switzerland)
14. Royal DSM N.V. (Netherlands)
15. Glentham Life Sciences Ltd. (UK)
16. Provita Nutrition Ltd. (UK)
17. Denk Ingredients GmbH (Germany)

Asia-Pacific

18. Ajinomoto Co., Inc. (Japan)
19. Kyowa Hakko Bio Co., Ltd. (Japan)
20. CJ CheilJedang Corp. (South Korea)
21. Daesang Corporation (South Korea)
22. Meihua Holdings Group Co., Ltd. (China)
23. Fufeng Group Ltd. (China)
24. Sumitomo Chemical Co., Ltd. (Japan)
25. Ningxia Eppen Biotech Co., Ltd. (China)
26. Vedan International Holdings Ltd. (Taiwan)
FAQs:
1. Which region has the largest share in the L-Histidine Market?
Ans: The North America region held the highest share in 2024 in the L-Histidine Market.

2. What are the key factors driving the growth of the L-Histidine Market?
Ans: Growing demand for the development of new drugs to boost the L-Histidine Market growth.

3. Who are the key competitors in the L-Histidine Market?
Ans: Ajinomoto Co., Inc., Kyowa Hakko Bio Co., Ltd. and Evonik Industries AG are the key competitors in the L-Histidine Market.

4. What are the opportunities for the L-Histidine Market?
Ans: Innovations in microbial fermentation and bioprocessing create opportunities in the L-Histidine Market.

5. Which Application segment dominates the L-Histidine Market?
Ans: The Pharmaceutical industry segment dominated the L-Histidine Market.