Microcarrier Market: Global Industry Analysis and Forecast (2024-2030)

Microcarrier Market was valued at USD 2.33 Billion in 2023, and it is expected to reach USD 4.84 Billion by 2030, exhibiting a CAGR of 11.02 % during the forecast period (2024-2030)

A microcarrier is a support matrix that permits adherent cells to proliferate in bioreactors. Instead of being cultivated on a flat surface, cells are cultured on the surface of spherical microcarriers, with each particle carrying hundreds of cells, allowing expansion capacity to be amplified many times over. It enables simple scaling up of culture systems for industrial production of cell or protein-based medicines or for research objectives. These solid or porous spherical matrices have a diameter of 100-300 um to provide for ample surface area while preserving enough cell adhesion and support, and their density is just above that of water (1 g/ml) to keep them suspended in a stirred tank.

They can be made of synthetic materials like acrylamide or natural ones like gelatin. The benefits of microcarrier technology in the biotech industry include (a) ease of scale-up, (b) the ability to precisely control cell growth conditions in sophisticated, computer-controlled bioreactors, (c) a reduction in the overall floor space and incubator volume required for a given-sized manufacturing operation, (d) a significant reduction in technician labour, and (e) a more natural environment for cell culture that promotes differentiation.

The ability to contain more cells in smaller quantities is a significant benefit of employing microcarrier suspensions for cell culture over typical two-dimensional plates. Microcarrier cell suspensions in stirred tank bioreactors provide uniform distribution via homogeneous stirring. Furthermore, mechanical stimulation promotes natural cell morphology and differentiation in the three-dimensional and high-density suspension environment. Two-dimensional plate culture, on the other hand, tends to de-differentiate cells across numerous passages, hence the total number of passes must be controlled. Microcarrier suspensions may also be readily scaled up by using higher concentrations of microparticles in bigger stirred tank reactors, while maintaining a small amount of laboratory space for growth. Furthermore, microcarriers are being researched as a means of delivering cells for targeted tissue engineering.To know about the Research Methodology:-Request Free Sample Report
Research Methodology
The research report highly depends on both primary and secondary data sources. The research process involves the investigation of various factors affecting the industry, such as government policy, market environment, competitive landscape, historical data, current market trends, technological innovation, upcoming technologies, and technical progress in related industries, as well as market risks, opportunities, market barriers, and challenges. All conceivable elements influencing the markets included in this research study have been considered, examined in depth, validated through primary research, and evaluated to provide the final quantitative and qualitative data. The market size for top-level markets and sub-segments is normalised, and the impact of inflation, economic downturns, regulatory & policy changes, and other variables is factored into the market forecast.

This data is combined and added with detailed inputs and analysis, and presented in the report. Extensive primary research was conducted to acquire information and verify and confirm the crucial numbers arrived at after comprehensive market engineering and calculations for market statistics; market size estimations; market forecasts; market breakdown; and data triangulation. Bottom-up technique is widely employed in the whole market engineering process, along with multiple data triangulation methodologies, to perform market estimation and forecasting for the overall market segments and sub-segments covered in this research.
Microcarrier Market Dynamics
Rising demand for cell-based vaccines: Population expansion, climate change, and more human-animal interaction have all raised the risk of new viral epidemics. For example, influenza and COVID-19 have shown to be unpredictable and recurrent phenomena that impose a large economic and social impact. The WHO reported 117.33 million cases of COVID-19 worldwide as of March 10, 2022, including 2.61 million fatalities. The rising prevalence of infectious illnesses, as well as the increased threat of pandemics, are predicted to boost global vaccination demand.

Cell culture is becoming an increasingly important aspect of vaccine manufacturing in the pharmaceutical business. Previously, vaccinations were created by cultivating and extracting viruses in chicken eggs, which was a time-consuming operation. Due to its shorter lead time and capacity to create vaccines in bigger numbers as needed, cell-based vaccine manufacturing has emerged as a significantly more efficient technology in this respect. Aside from these advantages, clinical research have shown that cell-based vaccinations are just as effective, safe, and efficient as egg-based vaccines.

Adherent cell production: The most extensively utilised strategy for scaling up adherent cell production is to culture them on tiny spherical beads called microcarriers in a stirred bioreactor. Microcarriers, which are generally approximately 100 m in diameter, bypass surface area limits by adding a dimension for cell growth. Microcarrier-based biomanufacturing has grown well established and currently constitutes a sizable business at all production sizes. Cell therapy is a growing market for microcarriers and has overtaken vaccine manufacturing as the second largest market sector. The bulk of cell treatments are now based on non-adherent hematopoietic lineage cells that do not require a support substrate. However, as the therapeutic potential of adherent MSC and iPSC-based therapeutics grows, so will the demand for biomanufacturing capacity capable of scaling up these adherent cell types.

Rising monoclonal antibody production: The increased popularity of targeted therapy options for diseases such as cancer and autoimmune and inflammatory disorders is driving up demand for monoclonal antibodies throughout the world. Because antibodies are given in high concentrations, the need for mAbs is also substantial. In December 2019, the FDA authorised 16 monoclonal antibody medicines globally, up from 10 in 2016. The bulk of these medications were approved for cancer and immune-related disorders.

Development of cost-effective cells: Microcarriers contribute to the creation of low-cost cells by reducing both variable and fixed costs in large-scale production. Because of technical advancements, the current situation has altered, and the role of microcarriers in cell treatment has increased. Dissolvable microcarriers, for example, are now available on the market and are composed of cross-linked polysaccharide polymers that dissolve readily during the cell harvesting process. Because the microcarriers are totally dissolved, there is no need for separation, and the downstream process operates smoothly. As a result, these microcarriers are seen as potentially valuable beads for large-scale cell treatment or cell manufacturing.

High cost of cell biology research: Cell biology entails considerable research and development of novel therapeutics such as stem cell and gene therapies. To deliver reliable findings, research equipment, media, reagents, and other goods must be of the highest quality. The cost of cell biology research has grown significantly as a result of the rising necessity to maintain high-quality standards (by the use of high-grade materials) and comply with regulatory body norms. As a result, many academic institutions and small businesses with limited funding are unable to pursue cell biology research. Because microcarriers are used in stem cell biology, this aspect is expected to limit market expansion. Furthermore, because microcarriers cling to cells, the cells must be collected, raising downstream processing costs. This is expected to restrain the growth of the microcarrier market.
Microcarrier Market Segment Analysis
Based on product, the Microcarriers market is segmented into equipment, consumables. Bioreactors, cell counters, culture containers, filtration systems, cell counters, and accessories are also sub-segmented under the equipment segment. Consumables are further classified as Media, Reagents, and Microcarrier beads. The consumables category is expected to expand the most over the analysis period due to the frequent purchasing of consumables for numerous research applications.

Based on application, the biggest revenue share for Microcarriers during the forecast period is expected to come from vaccine manufacturing. The growing frequency of infectious illnesses, the increased need for monoclonal antibodies, and the expansion of biopharmaceutical enterprises are the primary drivers of the segment's growth. Another advantage that Microcarrier technology provides to biopharmaceutical industries in the manufacture of vaccines is the ability to precisely control cell growth conditions in sophisticated, computer-controlled bioreactors, in addition to ease of scaling up, a reduction in technician labour and storage requirements, and a reduction in laboratory space requirements. Virus vaccines based on complex-structured glycoproteins and monoclonal antibodies. Animal cells are utilised in industrial processes to produce "bulk" vaccinations and other goods. Biologicals require large-scale bioreactors to be commercially available.Based on End User, Pharmaceutical and biotechnology companies, research institutions, and CROs are the different segments of the market. The pharmaceutical and biotechnology sectors are expected to dominate the Microcarriers market. This is because single-use technologies are increasingly being employed in vaccine manufacturing, and microcarriers are finding new applications. The research institutes category is expected to grow at the fastest rate due to increased need for research and development in life-threatening diseases. Several research facilities employ Microcarriers to help with patient health management. In the Microcarriers market, innovation, discovery, and development are driving demand since they assist to increase the efficacy of patient treatment.


Microcarrier Market Regional Insights
In the next years, North America is expected to have the largest global microcarrier market size. Increasing R&D activity for cell and gene treatments in order to generate the necessary vaccinations boosts market growth. Because of the increased need for vaccinations during pandemics, the divided area is able to control the worldwide market. Because of the increasing frequency of infectious and malignant conditions, as well as the expansion of the North America Microcarriers market in the next years, the development of NSG bioinformatics equipment, the presence of important companies in the area, and expenditures in R&D activities.

Due to expanding demand for monoclonal antibodies and vaccines, as well as increased Research & Development (R&D) operations from several large pharmaceutical firms, biopharmaceutical manufacturing retained the biggest revenue share in 2023. Furthermore, the rising number of regulatory approvals for vaccines is driving the expansion of this market. As of December 2019, the US Food and Drug Administration had authorised around 79 therapeutic monoclonal antibodies (FDA).

According to the American Cell and Gene Therapy Association, there will be 1,745 medicines under development from preclinical through preregistration by May 2022. Furthermore, viral vectors are used for delivery in around 89% of gene treatments in development. In addition to the existence of large pharmaceutical and biotechnology corporations, the market is growing due to fast technical progress and increased high-value expenditures in cell-based research. More sophisticated therapeutic and regenerative medicine developers are based in North America.

Europe is the second-largest region with a worldwide market share. The increasing use of technical developments helps the market's top players to maintain control. Increased use of R&D activities is expected to improve product development and market demand. Asia Pacific is expected to have a higher CAGR during the forecast period due to an increase in chronic illness incidence, which would lead to increased investments in research such as stem cell, cell biology, and so on. Latin America and the Middle East and Africa are expected to see slower market expansion due to inadequate infrastructural development and healthcare budget constraints that limit R&D activity.
Report Scope:
The Microcarrier Market research report includes product categorization, product application, development trend, product technology, competitive landscape, industrial chain structure, industry overview, national policy and planning analysis of the industry, and the most recent dynamic analysis, among other things. The study discusses the worldwide market's drivers, opportunities, and limitations. It discusses the influence of various drivers, trends, and constraints on market demand during the forecast period. The research also outlines market potential on a global scale. The research includes the production time, base distribution, technical characteristics, research and development trends, technology sources, and raw material sources of significant Microcarrier Market firms in terms of production bases and technologies. The more precise research also contains the key application areas of market and consumption, significant regions and consumption, major producers, distributors, raw material suppliers, equipment providers, and their contact information, as well as an analysis of the industry chain relationship. This report's study also contains product specifications, manufacturing processes, cost structure, and data information organised by area, technology, and application.
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Microcarrier Market


Report Coverage
Details


Base Year:
2023
Forecast Period:
2024-2030


Historical Data:
2018 to 2023
Market Size in 2023:
US $ 2.33 Bn.


Forecast Period 2024 to 2030 CAGR:
11.02%
Market Size in 2030:
US $ 4.84 Bn.


 Segments Covered:
by Product
Equipment
Consumables


by Application
Vaccine Manufacturing
Cell Therapy
Other Applications


by End-User
Pharmaceutical and Biotechnology Companies
Research Institutes
CROs


by Material Type
Alginate based,
collagen based,
Dextran based
Polystyrene based
Others



Microcarrier Market, by Region
North America (United States, Canada and Mexico)
Europe (UK, France, Germany, Italy, Spain, Sweden, Austria and Rest of Europe)
Asia Pacific (China, South Korea, Japan, India, Australia, Indonesia, Malaysia, Vietnam, Taiwan, Bangladesh, Pakistan and Rest of APAC)
Middle East and Africa (South Africa, GCC, Egypt, Nigeria and Rest of ME&A)
South America (Brazil, Argentina Rest of South America)
Microcarrier Market, Key Players are:
1. Thermo Fisher Scientific Inc. (US)
2. Sartorius AG (Germany)
3. Cytiva (US)
4. Danaher Corporation (US)
5. Eppendorf AG (Germany)
6. Merck & Co., Inc.(US)
7. ChemoMetec (Denmark)
8. CESCO Bioengineering (Taiwan)
9. HiMedia Laboratories (India)
10.Corning Incorporated (US)
11.Becton – Dickinson and Company (US)
12.Lonza (Switzerland)
13.denovoMATRIX GmbH (Germany)
14.Bio-Rad Laboratories, Inc. (US)
15.Sigma Aldrich (US)
16.General Electric (US)

Frequently Asked Questions:

1. What is the forecast period considered for the Microcarrier Market report?
Ans. The forecast period for the Microcarrier Market is 2024-2030.

2. Which key factors are hindering the growth of the Microcarrier Market?
Ans. cost of cell biology research has risen considerably these key factors are hindering the growth of Microcarrier market.

3. What is the compound annual growth rate (CAGR) of the Microcarrier Market for the forecast period?
Ans. 11.02% (CAGR) is the Annual growth rate of Microcarrier market for forecast period.

4. What are the key factors driving the growth of the Microcarrier Market?
Ans. Microcarriers contribute to the development of cost-effective cells by minimizing both variable and fixed costs in large-scale production driving the growth of Microcarrier market.

5. Which are the worldwide major key players covered for the Microcarrier Market report?
Ans. Danaher Corporation, Lonza, Sartorius AG, Eppendorf AG, HiMedia Laboratories are the major key players covered in the Microcarrier market.