Bioactive Materials Market: Global Industry Analysis and Forecast (2023-2029)

The Global Bioactive Materials Market size was valued at USD 2408.32 Million in 2022 and the total Bioactive Materials revenue is expected to grow at a CAGR of 14.5% from 2023 to 2029, reaching nearly USD 6213.73 Million.

Bioactive materials, integral to various fields of dentistry and medicine, play a pivotal role in tissue regeneration, repair, and reconstruction, particularly in conservative dentistry and endodontics. These innovative materials, distinct from traditional bio-inert biomaterials, represent a new generation of biomaterials. Traditionally, biomaterials are non-viable substances used in medical devices for interaction with biological systems.

However, bioactive materials stand out by possessing a unique blend of chemical, mechanical, physical, and biological properties that make them exceptionally suitable for safe, effective, and reliable utilization within physiological environments. This makes them indispensable in modern healthcare and dental practices. Thus, the Bioactive Materials Market is experiencing a significant transformation across various fields.

The rising demand for advanced implantable materials, with a particular focus on replacing conventional metal implants is expected to be the prime factor driving the Bioactive Materials Market growth during the forecast period. Bioactive materials exhibit exceptional bonding capabilities with bodily fluids and tissues, making them indispensable for tissue healing and repair in the medical and healthcare sectors. Moreover, they find extensive applications in producing antibacterial products, pharmaceuticals, cosmetics, and beyond, driving the Bioactive Materials market growth.

Additionally, the adoption of advanced technologies in the medical sector, coupled with increased investments in healthcare infrastructure and surgical techniques, is further increasing the global bioactive materials market's growth. The rising demand for knee and joint replacement surgeries is further expected to support the industry's growth. Recent trends like bioengineering and tissue engineering, along with innovations in drug delivery technologies, are further increasing the revenue share of the market. Porous-coated and fully or partially porous orthopedic implants are gaining popularity due to improved osseointegration and survivorship rates, adding to the positive outlook of the bioactive materials market.To know about the Research Methodology :- Request Free Sample Report
Bioactive Materials Market Competitive Landscapes:
The Global Bioactive Materials market is expected to be highly competitive active presence of numerous market players. Major companies are striving to introduce cost-efficient and advanced implant-focused products to meet the increasing demand, consequently fostering overall market growth. In addition, the Bioactive Materials industry's growth is significantly influenced by research institutions and government backing for product approvals and technological advancements. Key players are adopting various business strategies, including technical partnerships and mergers and acquisitions (M&A) to remain competitive in the bioactive materials market. For instance,

• January 05, 2023: Zimmer Biomet Holdings, Inc., a global medical technology leader, announced a definitive agreement to acquire Embody, Inc., a privately-held medical device company that focuses on soft tissue healing, for USD 155 million at closing and up to an additional USD 120 million subject to meeting future regulatory and commercial milestones over three years.

• August 6, 2021: Medtronic plc., the global leader in medical technology, declared that it has entered into a definitive agreement with Intersect ENT, a global ear, nose, and throat (ENT) medical technology leader committed to developing patient care, in which Medtronic will acquire all outstanding shares of Intersect ENT for USD 28.25 per share in an all-cash transaction implying a USD 1.1 billion enterprise value.

• October 04, 2022: Stryker, one of the world's top medical technology firms, has introduced the Monterey AL Interbody System, a stand-alone interbody fusion device for anterior lumbar interbody fusion (ALIF). The Monterey AL implant incorporates both solid and porous components into a single implant, utilizing Stryker's patented Tritanium In-Growth Technology, a substance designed to resemble cancellous bone and offer an environment conducive to bone regeneration and fusion. New research shows that undifferentiated stem cells cultured on Tritanium produce osteogenic Alkaline Phosphatase without the need for growth factors.
Bioactive Materials Market Dynamics:
Increasing Adoption in Soft Tissue Repair

The growing aging population all across the world is expected to be the major driver for the Bioactive Materials Market. Age-related pathologies have surged in recent decades, necessitating efficient solutions for tissue repair. Biomaterials/ scaffolds play a pivotal role in tissue regeneration by facilitating three-dimensional tissue growth and harnessing the body's innate regenerative mechanisms. Bioceramics like calcium phosphates, bioactive glasses, and glass ceramics have emerged as promising biomaterials, especially when combined with polymers to create composite scaffolds. Traditionally used for hard tissue repair, bioceramics are now making significant inroads in soft tissue engineering.

Soft tissues, frequently subjected to damage from burns, trauma, tumors, and degeneration, require advanced interventions. These scaffolds not only support cell adhesion, proliferation, and differentiation akin to autologous tissues but also serve as drug-delivery systems. By incorporating therapeutic molecules, biomimetic scaffolds enhance their biological performance, leading to innovative products with multifunctional capabilities.

As the elderly population continues to expand, the demand for effective soft tissue repair solutions is poised for sustained growth. The Bioactive Materials Market is primed to capitalize on this trend, offering biomaterials that not only heal but also improve patients' quality of life. With their versatility and regenerative potential, bioceramics and composite scaffolds represent a cornerstone in the quest for advanced therapies, making them a crucial driver in the realm of regenerative medicine and bioactive materials.
High Demand in Conservative Dentistry and Endodontics

The rapidly increasing demand for bioactive materials in conservative dentistry and endodontics is expected to be the major factor supporting the global bioactive materials market. This growth is driven by their remarkable ability to facilitate tissue regeneration, repair, and reconstruction in the dental field. Bioactive materials are characterized by their capacity to interact with living tissues, organisms, or cells, inducing responses like hydroxyapatite formation. These materials play a pivotal role in promoting tissue healing, and maintaining pulp vitality, and exhibit ideal properties such as bactericidal, bacteriostatic, and sterility.

The concept of biomimetics, emulating natural biological processes and structures, underscores the development of bioactive materials. In dentistry, these materials excel due to their ability to spontaneously generate an apatite layer when exposed to phosphate-containing physiological fluids. This apatite formation, facilitated by the interaction of released Ca2+ ions with phosphates, forms the basis for various inorganic biomaterials like glass ceramics.

Moreover, bioactive materials trigger cytological and functional changes in pulpal cells, fostering reparative dentin formation. They support the proliferation, migration, and differentiation of odontoblast-like cells, leading to collagen matrix production. This unmineralized matrix eventually undergoes mineralization through osteodentin and tertiary dentin formation. In essence, bioactive materials revolutionize conservative dentistry and endodontics by enhancing dental treatments and promoting optimal oral health.

High Cost of Production and Stringent Regulatory Approvals

The High Cost of Production and Stringent Regulatory Approvals are expected to be the key restraints for the Bioactive Materials market growth. The development and manufacturing of bioactive materials involve intricate processes and the use of specialized raw materials. These factors contribute to elevated production costs. These high costs pose a barrier to entry for smaller manufacturers and are expected to result in expensive end products. As a consequence, the adoption of bioactive materials may be limited in regions or healthcare systems with budget constraints. It also affects the affordability of medical devices and treatments that incorporate these materials, potentially reducing their accessibility to a broader patient population.

In addition, bioactive materials intended for use in medical devices and healthcare applications are subject to stringent regulatory oversight. Regulatory agencies like the FDA in the United States demand extensive testing and documentation to ensure the safety and efficacy of these materials. Obtaining regulatory approvals can be a protracted and resource-intensive process. Delays in approvals can postpone market entry, and the associated costs can be substantial. Moreover, meeting evolving regulatory standards can necessitate ongoing investments in research and development, adding to the overall expense.
Bioactive Materials Market Trends:
Increasing Plastic Surgeries all across the world

The rising number of plastic surgeries is poised to have a significant impact on the bioactive materials market. These procedures, encompassing a wide range of cosmetic and reconstructive surgeries, are increasingly reliant on bioactive materials for enhanced outcomes and safety. The number of cosmetic operations in the plastic surgery department of the hospital increased by 49.4% in 2021, compared to 2020, and increased by 29.7% compared to 2019. The number of operations in all disciplines increased by 33.4% in 2021, compared to 2020, and increased by 13.3% compared to 2019.

The growing societal emphasis on appearance and beauty standards is expected to be the major factor driving the number of plastic surgeries all across the world. As more individuals seek cosmetic enhancements to meet these ideals, the demand for bioactive materials surges. Bioactive materials play a pivotal role in various aspects of plastic surgery, from tissue regeneration to the development of advanced implants, ensuring safer and more effective procedures.
According to the MMR analysis, South Korea is the country with the highest percentage of plastic surgeries in the world, and this is followed by Greece and Italy. The United States falls below the fifth rank of plastic surgery by country. The rates of plastic surgery in a country are influenced by its economy and the disposable income of its citizens. Wealthier countries like Greece and South Korea have higher rates of elective plastic surgery, driven by the availability of disposable income for such luxuries.

In South Korea, it's estimated that approximately one in five individuals has undergone or is considering plastic surgery, with women being the largest demographic seeking these procedures. Common surgeries in South Korea include nose jobs, liposuction, and blepharoplasty (double eyelid surgery). Blepharoplasty in South Korea is often sought to achieve a more Westernized look rather than addressing wrinkles, typically involving the removal of excess eye fat and correction of eye drooping.

In some countries like Brazil, the government offers subsidies or tax relief to incentivize plastic surgery. In Brazil, there's no stigma associated with cosmetic procedures, and they are even seen as a symbol of status. Liposuction and breast implants are particularly popular in the country.
Bioactive Materials Market Segment Analysis:
By Material, the Bioactive Glass segment dominated the global bioactive materials market with the highest market share of 38% in 2022. The segment is further expected to grow at a CAGR of 14.8% and maintain its dominance during the forecast period. Thanks to its unique properties such as biocompatibility, bioactivity, and versatility bioglass is widely adopted in various medical applications, such as bone tissue engineering, drug delivery, and dentistry, and as a scaffold and grafting material, is driving a substantial increase in the demand for bioactive glass, thereby driving segment growth. Their ability to promote tissue integration, coupled with ongoing research for innovative compositions and antibacterial applications, fuels the segment growth. Clinical trials further validate their safety and efficacy in real-world scenarios, driving their adoption. With customization options and a promising future in regenerative medicine, the bioactive glasses segment is expected to continue to increase the bioactive materials market growth during the forecast period.

The Bioactive glass-ceramics segment is expected to grow at a significant CAGR and offer lucrative growth opportunities for the bioactive materials market players during the forecast period. Bioactive glass ceramics, characterized by their unique blend of properties, including biocompatibility and bioactivity, hold immense promise in various biomedical applications. These advanced materials are gaining traction due to their ability to form strong bonds with biological tissues, making them ideal for applications like bone tissue engineering, dental implants, and drug delivery systems. Their biodegradable and bone-bonding attributes make them particularly attractive for regenerative medicine. The increasing awareness of its versatile applications and the ongoing research to enhance its properties are expected to be the major factors driving the segment's growth.
Techniques for Making Bioactive Ceramics




Method
Advantage
Disadvantage


Meltquenching technique
There is mass production
1. These glasses' nonlinear properties

2. Nanoparticle surface imperfections and an impure semiconductor composition

3. Utilized to get around the inability of this method to produce thin films


Sol-Gel
1. Best suited for deposition on a variety of substrates, including glass wool and silica/glass rushing rings.

2. Straightforward homogeneity, repeatability, affordable cost, dependability, and controllability

3. On substrates with complex forms and a large surface area, films can be easily fixed.
1. A lengthy deposition period

2. A dense coating of Nanoparticles cannot be attached to the substrate.

3. Forming anatase nanocrystals at a high temperature

4. High cost of fabrication


Spray pyrolysis
1. Continuous process

2. Has shorter processing times

3. No vacuum needed

4. Generate supplies by synthesizing them as powders and films
1. Scaling up is difficult.

2. Low yield

3. Difficulties determining the growing temperature


Spray Drying
1. Continuous and fully automated.

2. Suitable for both heat-resistant and heat-sensitive goods.

3. It is possible for spherical particles.
1. Not established particles with microstructures.

2. Rapid dosage form rates and outcomes pop.


Modified Stöber
1. Produce nearly monodisperse silica particles

2. Provides an excellent model for investigating colloidal phenomena

3. Enabling the manufacture of controlled-size spherical monodisperse silica particles
1. Aerogel is delicate.



The evolving role of glass from a passive material to an active one marks a significant transformation in healthcare, particularly in the 21st century. Bioactive glasses (BGs) and glass ceramics (BGCs) are emerging as functional biomaterials with immense potential in the realm of cancer therapy. These materials, often derived from melting or gelling processes, have the unique ability to incorporate various exotic elements, including rare-earth elements. This capability enables them to exhibit highly effective anti-cancer properties, encompassing radiotherapy, photothermal therapy, magnetic hyperthermia, and the delivery of therapeutic drugs or ions.

Doping these materials with specific elements not only alters their bioactivity but also imparts novel functionalities, triggering biological effects that are unparalleled by other biomaterial categories. Bioactive glasses and ceramics represent a rapidly expanding field with profound implications for various medical applications. These materials have already demonstrated their potential in bone regeneration, dental implant enhancements, cancer therapy, and innovative approaches to wound healing. As research in this domain advances, it is evident that bioactive glasses and ceramics are poised to become integral components of modern medical solutions.
Bioactive Materials Market Regional Insights:
The North American region led the global bioactive materials market with the highest market share of 41.26% in 2022. The region is further expected to grow at a CAGR of 14.9% during the forecast period and maintain its dominance by 2029. The increasing number of orthopedic and dental surgeries, well-established healthcare infrastructure, and significant investment to advance the medical technology sector are expected to be the major factors driving regional growth. The United States is expected to be the key region for the Bioactive Materials Market. The country’s continuous investments in medical technology advancements are a major factor supporting regional growth. In the United States, the healthcare industry stands as one of the most advanced across the region. According to the MMR analysis, the country is expected to witness robust growth in national healthcare spending from 2021 to 2028, with an average annual increase of over 5.5%. This substantial investment in healthcare infrastructure creates lucrative opportunities for the utilization of bioactive materials.

In addition, the increasing aging population across the region is expected to further boost the Bioactive Materials market growth. According to the analysis, the population aged 65 and above in the United States constitutes approximately 16.6% of the total population. This elderly demographic requires increased medical attention, particularly for issues related to tooth decay, gum problems, and an elevated risk of arthritis. Thus, bioactive materials become indispensable in addressing these healthcare needs. Moreover, musculoskeletal diseases and joint replacements, particularly knee and hip replacements, are prevalent surgical procedures among the American population. The utilization of bioactive materials in these applications is rapidly increasing, reflecting their critical role in enhancing patient outcomes and post-surgery recovery.
States by Percent of Population Age 65 or Older, 2020




State
Total Resident Population (thousands)
Population Ages 65+ (thousands)
Population Ages 65+ (percent of state population)


California
39,368
5,976
15.2


Florida
21,733
4,638
21.3


Texas
29,361
3,874
13.2


New York
19,337
3,370
17.4


Pennsylvania
12,783
2,448
19.1


Ohio
11,693
2,098
17.9


Illinois
12,588
2,089
16.6


North Carolina
10,601
1,815
17.1


Michigan
9,967
1,812
18.2


Georgia
10,710
1,575
14.7


New Jersey
8,882
1,510
17


Virginia
8,591
1,401
16.3


Arizona
7,421
1,374
18.5


Washington
7,694
1,248
16.2


Massachusetts
6,894
1,198
17.4


Tennessee
6,887
1,181
17.1


Indiana
6,755
1,115
16.5


Missouri
6,152
1,090
17.7


Wisconsin
5,833
1,048
18



Canada, further expected to be a significant player in the North American healthcare landscape, also contributes to the regional growth of the bioactive materials market. The Canadian healthcare industry is marked by a diversified and export-oriented medical device sector, which manufactures a wide range of equipment and supplies. This sector thrives on continuous product innovations and draws upon cutting-edge research conducted in Canadian universities, research institutes, and hospitals. This research often translates into the development of bioactive materials that find applications in medical devices and pharmaceuticals, further propelling the bioactive materials market growth.

The Asia-Pacific region, with countries like China, India, and Japan, is emerging as a vital player in the bioactive materials market. Rapid urbanization, a growing middle-class population, and increasing healthcare awareness are expected to be the major factors driving the demand for bioactive materials. Dental and orthopedic applications are witnessing substantial growth. Moreover, the region's economic growth is leading to greater healthcare expenditure, which, in turn, boosts market growth. China, in particular, is becoming a hub for bioactive materials production due to its large population base and low manufacturing costs, thereby supporting market growth.
Bioactive Materials Market Scope: Inquiry Before Buying



Bioactive Materials Market


Report Coverage
Details


Base Year:
2022
Forecast Period:
2023-2029


Historical Data:
2018 to 2022
Market Size in 2022:
US $ 2408.32 Mn.


Forecast Period 2023 to 2029 CAGR:
14.5%
Market Size in 2029:
US $ 6213.73 Mn.


 Segments Covered:
by Material
Bioactive glass
Bioactive glass-ceramics
Bioactive ceramics
Bioactive composites
Others


by Type
Powder
Granules
Moldable & Injectable
Other


by Application
Orthopaedics
Dentistry
Nanomedicines and Biotechnology
Others



Bioactive Materials Market by Region:
North America (United States, Canada, and Mexico)
Europe (UK, France, Germany, Italy, Spain, Sweden, Austria, and the Rest of Europe)
Asia Pacific (China, South Korea, Japan, India, Australia, Indonesia, Malaysia, Vietnam, Taiwan, Bangladesh, Pakistan, and the Rest of APAC)
Middle East and Africa (South Africa, GCC, Egypt, Nigeria, and the Rest of ME&A)
South America (Brazil, Argentina Rest of South America)
Bioactive Materials Market Key Players:
1. Biomatlante (Vigneux de Bretagne, France)
2. Arthrex Inc. (Naples, Florida, USA)
3. Pulpdent Corporation (Watertown, Massachusetts, USA)
4. Bioactive Bone Substitutes OY (Turku, Finland)
5. Lasaks.r.o (Prague, Czech Republic)
6. Smith & Nephew PLC (London, United Kingdom)
7. Medtronic Inc. (Dublin, Ireland)
8. Stryker Corporation (Kalamazoo, Michigan, USA)
9. AapImplantate (Berlin, Germany)
10. DePuy Synthes (Warsaw, Indiana, USA)
11. Zimmer Holding Inc. (Warsaw, Indiana, USA)
12. Biomet Inc. (Warsaw, Indiana, USA)
13. Baxter International, Inc. (Deerfield, Illinois, USA)
14. CONMED Corporation (Utica, New York, USA)
15. Bioretec Ltd. (Tampere, Finland)
16. Noraker (Cournon d'Auvergne, France)
17. Septodont Holding (Saint-Maur-des-Fossés, France)
18. C.I. TAKIRON Corporation (Osaka, Japan)
19. BTG (Boston Scientific) (London, United Kingdom)
20. Cam Bioceramics (Leiden, Netherlands)
21. Ceraver (Roissy-en-France, France)
22. Collagen Matrix Inc. (Oakland, New Jersey, USA)
23. DSM (Heerlen, Netherlands)
24. Evonik Industries (Essen, Germany)
25. OSARTIS GmbH (Dieburg, Germany)
FAQs:
1. What are the growth drivers for the Bioactive Materials market?
Ans. The rising demand for advanced implantable materials, with a particular focus on replacing conventional metal implants is expected to be the major driver for the Bioactive Materials market.

2. What is the major restraint on the Bioactive Materials market growth?
Ans. High Cost of Production and Stringent Regulatory Approvals are expected to be the major restraining factors for the Bioactive Materials market growth.

3. Which region is expected to lead the global Bioactive Materials market during the forecast period?
Ans. North America is expected to lead the global Bioactive Materials market during the forecast period.

4. What is the projected market size & and growth rate of the Bioactive Materials Market?
Ans. The Bioactive Materials Market size was valued at USD 2408.32 Million in 2022 and the total Bioactive Materials revenue is expected to grow at a CAGR of 14.5% from 2023 to 2029, reaching nearly USD 6213.73 Million.

5. What segments are covered in the Bioactive Materials Market report?
Ans. The segments covered in the Bioactive Materials market report are Material, Type, Application, and Region.