The
3D Bioprinting Industry reached a size of USD 1.63 Bn. in 2023 and is expected to increase at a CAGR of 20.07%, potentially generating USD 5.08 Bn. in revenue by 2030. The global 3D bioprinting industry is a dynamic Industry significantly influencing healthcare through innovative technologies and strategic collaborations. Leading companies in the 3D Bioprinting Industry invest heavily in research and development to enhance bioprinting technologies, resulting in the creation of more sophisticated and functional tissues for medical applications. These advancements are revolutionizing regenerative medicine by producing tissues and organs that closely resemble human tissues, enabling their use in treating various diseases and injuries. As the industry continues to grow, its applications in personalized medicine and drug testing are also increasing, further solidifying its impact on healthcare and improving patient outcomes. This evolving landscape highlights the potential of 3D bioprinting to transform medical treatments and practices globally.
A competitive analysis of the 3D bioprinting Industry reveals significant advancements in R&D, along with strong partnerships between academic and industrial institutions. Regulatory challenges are also key factors shaping the industry's growth. Leading companies such as Organovo, CELLINK, and Cyfuse Biomedical K.K. are leading innovation, and positioning themselves as frontrunners in this rapidly evolving field. Their efforts are driving technological progress and shaping the future of 3D bioprinting across various applications, from tissue engineering to pharmaceutical development.
Organovo
Organovo, is one of the leading companies in the 3D bioprinting industry, which is focused on developing and commercializing functional 3D human tissues using proprietary bioprinting technology. The company’s bioprinted tissues closely mimic human tissue architecture and functions, serving applications in drug discovery, biological research, and therapeutic implants. Organovo has developed a suite of standardized 3D human tissues to enhance preclinical drug testing, including predictive toxicology and pharmacokinetics studies, aiming to improve upon traditional animal and cell-based testing models. Additionally, the company offers highly customized human tissues for disease modeling and drug development. A significant development is their therapeutic liver tissue patch, designed for clinical applications. Organovo began commercializing its offerings in November 2014 with contract research services and continues to explore future applications in tissue transplantation. With ongoing innovations, Organovo is positioned to capitalize on growing opportunities within the 3D bioprinting industry.
CELLINK
CELLINK, a leading companies in the 3D bioprinting industry, has revolutionized the field through advanced bioprinters and innovative cell culture solutions. Their flagship products, such as the BIO X and BIO X6, enable researchers to create complex 3D cell culture scaffolds with ease. CELLINK’s focus on accessibility has democratized 3D bioprinting, making it more feasible for labs worldwide to adopt. The BIO ONE, launched in February 2024, simplifies the transition to 3D cell culture, featuring a cooled syringe printhead that enhances consistency with temperature-sensitive materials like Matrigel® and collagen, improving efficiency by over 800%. CELLINK’s continuous innovations in extrusion and light-based bioprinting, alongside their parent company BICO’s lab automation expertise, position them at the forefront of this rapidly expanding Industry, with a growing presence in pharmaceutical research and tissue engineering applications.
Cyfuse Biomedical K.K.
Cyfuse Biomedical K.K. is one of the leading companies in the 3D bioprinting industry, which is known for its innovative Bio 3D Printer technology and leverages its proprietary cell stacking method. This technology uses needle arrays to position spheroids, allowing cells to fuse naturally and form complex 3D cellular structures, including tissues and organs. Cyfuse's Bio 3D Printer has achieved significant breakthroughs in regenerative medicine, particularly in the regeneration of cartilage, bone, blood vessels, and nerves. Additionally, the technology is being utilized for disease models and drug discovery tools, enabling more accurate toxicity and efficacy testing of new drugs. With a focus on global expansion and integration of biological and engineering expertise, Cyfuse is pushing the boundaries of 3D bioprinting. Their Bio 3D Printer provides a robust platform for researchers and engineers, driving advancements in tissue engineering and regenerative medicine while meeting growing demand in these fields.
Recent development
• On January 27, 2021, 3D Systems announced a major growth of its regenerative medicine and bioprinting initiatives, which is driven by collaboration with United Therapeutics. The company revealed a breakthrough in high-rate, micron-level printing technology that enables vascularization crucial for sustaining living cells, opening new application opportunities within the human body. The new Print to Perfusion™ process facilitates the rapid production of vascularized, high-resolution scaffolds for drug testing. 3D Systems plans to increase investment to commercialize these applications and reduce reliance on animal testing.
• On December 12, 2023, FluidForm Bio announced significant advancements in engineered heart tissues using its FRESH™ 3D bioprinting technology. A recently published study in *APL Bioengineering* highlighted how FRESH™ creates a predictive model for human cardiac physiology, addressing gaps in existing drug development models. By utilizing human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), FluidForm achieved high cell densities and alignment, improving physiological function. The technology enhances tissue viability and reproducibility, reinforcing FluidForm's commitment to developing lifelike tissues for therapeutic applications.